Introduction <p>Due to immunosenescence, geriatric populations have a heightened vulnerability towards severe COVID-19 disease as well as disease complications during the course of illness. Insidious onset immune-mediated thrombocytopaenia during the recovery phase poses a significant challenge in its detection and management, especially among hospitalised elderly patients who might lack telltale signs till the platelet count becomes significantly reduced.</p> Case Report <p>A 93-year-old lady with underlying hypertension, a previous stroke, and recent right hip hemiarthroplasty was treated in our institution initially for COVID-19 infection. Prior to discharge, her repeated platelet level dropped precipitously from 182 × 10<sup>9</sup>/L to 6 × 10<sup>9</sup>/L within the span of 5&#xa0;days. Medications that could potentiate bleeding complications were withheld promptly after recognising the new onset thrombocytopaenia. Following the consultation with haematologist, she was diagnosed with immune-mediated thrombocytopaenia induced by COVID-19 infection and started on intravenous hydrocortisone therapy. Her platelet level recovered remarkably after 3&#xa0;days of intravenous hydrocortisone and she was eventually discharged well with a short course of prednisolone.</p> Conclusion <p>This report underscores the importance of recognising delayed onset thrombocytopaenia in COVID-19 among elderly patients, which is believed to have a viral induced immunological aetiology. It warrants a timely institution of steroidal therapy to increase the platelet count as well as prompt discontinuation of concurrent medications that could potentiate bleeding complications in the presence of critical thrombocytopaenia.</p>

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Immune-Mediated Thrombocytopaenia in a Nonagenarian: A Fortuitous Discovery During COVID-19 Recovery Phase—A Case Report

  • Thai Lun Tan,
  • Navin Kumar Sarkunam,
  • Chuan Jin Tan,
  • Lai Chee Chow,
  • Azureen Binti Azmel

摘要

Introduction

Due to immunosenescence, geriatric populations have a heightened vulnerability towards severe COVID-19 disease as well as disease complications during the course of illness. Insidious onset immune-mediated thrombocytopaenia during the recovery phase poses a significant challenge in its detection and management, especially among hospitalised elderly patients who might lack telltale signs till the platelet count becomes significantly reduced.

Case Report

A 93-year-old lady with underlying hypertension, a previous stroke, and recent right hip hemiarthroplasty was treated in our institution initially for COVID-19 infection. Prior to discharge, her repeated platelet level dropped precipitously from 182 × 109/L to 6 × 109/L within the span of 5 days. Medications that could potentiate bleeding complications were withheld promptly after recognising the new onset thrombocytopaenia. Following the consultation with haematologist, she was diagnosed with immune-mediated thrombocytopaenia induced by COVID-19 infection and started on intravenous hydrocortisone therapy. Her platelet level recovered remarkably after 3 days of intravenous hydrocortisone and she was eventually discharged well with a short course of prednisolone.

Conclusion

This report underscores the importance of recognising delayed onset thrombocytopaenia in COVID-19 among elderly patients, which is believed to have a viral induced immunological aetiology. It warrants a timely institution of steroidal therapy to increase the platelet count as well as prompt discontinuation of concurrent medications that could potentiate bleeding complications in the presence of critical thrombocytopaenia.