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Background <p>Diabetes mellitus (DM) is a growing global health crisis. LADA represents a distinct form of&#xa0;diabetes, sharing characteristics of both type 1 (T1DM) and type 2 diabetes mellitus (T2DM),&#xa0;making its accurate diagnosis and management particularly challenging.</p> Objective <p>This review aims to comprehensively explore latent autoimmune diabetes in adults (LADA),&#xa0;synthesizing current knowledge on its prevalence, pathogenesis, diagnostic challenges, and&#xa0;management strategies, while also identifying gaps in understanding to guide future research.</p> Key Findings <p>LADA accounts for 2–12% of diabetic patients. Its complex pathogenesis involves both&#xa0;autoimmune and genetic factors. Clinical ambiguity often leads to misdiagnosis, delaying&#xa0;appropriate management. This review outlines key diagnostic criteria, details effective&#xa0;management strategies that integrate approaches from both T1DM and T2DM, and emphasizes&#xa0;the importance of personalized medicine.</p> Conclusion <p>This review serves as a valuable resource for clinicians, enhancing diagnostic accuracy and&#xa0;facilitating tailored treatment for LADA patients. It also establishes a robust foundation for&#xa0;future research focused on elucidating LADA’s pathophysiology, refining diagnostic tools, and&#xa0;developing innovative therapeutic interventions to improve patient outcomes.</p>

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LADA: The Evolving Landscape of Adult-Onset Autoimmune Diabetes

  • 期刊论文

  • 发表日期：

    2025年8月13日

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  • Maneeth Mylavarapu,
  • Lakshmi Sravya Popuri,
  • Niharika Tanwar,
  • Ankur Singla,
  • Fabeha Zafar,
  • Dharma Rayaprolu,
  • Yaswanth Kancharla,
  • Diptish Wankhade,
  • Sara Cherkos Dawit

摘要

Background

Diabetes mellitus (DM) is a growing global health crisis. LADA represents a distinct form of diabetes, sharing characteristics of both type 1 (T1DM) and type 2 diabetes mellitus (T2DM), making its accurate diagnosis and management particularly challenging.

Objective

This review aims to comprehensively explore latent autoimmune diabetes in adults (LADA), synthesizing current knowledge on its prevalence, pathogenesis, diagnostic challenges, and management strategies, while also identifying gaps in understanding to guide future research.

Key Findings

LADA accounts for 2–12% of diabetic patients. Its complex pathogenesis involves both autoimmune and genetic factors. Clinical ambiguity often leads to misdiagnosis, delaying appropriate management. This review outlines key diagnostic criteria, details effective management strategies that integrate approaches from both T1DM and T2DM, and emphasizes the importance of personalized medicine.

Conclusion

This review serves as a valuable resource for clinicians, enhancing diagnostic accuracy and facilitating tailored treatment for LADA patients. It also establishes a robust foundation for future research focused on elucidating LADA’s pathophysiology, refining diagnostic tools, and developing innovative therapeutic interventions to improve patient outcomes.