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Background <p>We are sharing a case about a 50-year-old woman who was diagnosed with stage IIIC triple-negative inflammatory breast cancer (TNIBC) back in July 2023.</p> Case Presentation <p>Even after going through a tough treatment plan that included neoadjuvant chemoimmunotherapy, surgery, radiation, olaparib, and sacituzumab govitecan (SG), her condition progressed to metastatic stage IV in just 6 months. Notably, her disease demonstrated significant lymphovascular invasion and 12 of 27 positive lymph nodes at surgery, despite apparent clinical response.</p> Conclusion <p>This case illustrates clinical-pathologic discordance and underlines the urgent need for novel predictive biomarkers and therapeutic strategies.</p>

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Metastatic Progression in Triple-Negative Inflammatory Breast Cancer Despite State-of-the-Art Treatment

  • 期刊论文

  • 发表日期：

    2025年7月23日

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  • Nasim Salimiaghdam,
  • Irene Pokuaa,
  • Ahmed Mustafa,
  • Erica Linden

摘要

Background

We are sharing a case about a 50-year-old woman who was diagnosed with stage IIIC triple-negative inflammatory breast cancer (TNIBC) back in July 2023.

Case Presentation

Even after going through a tough treatment plan that included neoadjuvant chemoimmunotherapy, surgery, radiation, olaparib, and sacituzumab govitecan (SG), her condition progressed to metastatic stage IV in just 6 months. Notably, her disease demonstrated significant lymphovascular invasion and 12 of 27 positive lymph nodes at surgery, despite apparent clinical response.

Conclusion

This case illustrates clinical-pathologic discordance and underlines the urgent need for novel predictive biomarkers and therapeutic strategies.