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<p>Lipoleiomyoma (LL) is a rare variant of leiomyoma comprising admixture of adipocytes and mature smooth muscle cells in variable proportion. It can be diagnosed as an incidental finding or occur in association with other common gynecological conditions driven by hyperestrogenic state like adenomyosis, endometrial polyp, endometrial hyperplasia and endometrial carcinoma. A pre-operative diagnosis is difficult due to overlapping features with other fat containing tumors. Herein, we report an interesting case of submucosal LL in association with endometrioid carcinoma in an elderly woman with the review of literature. A 69-year-old lady was presented with the complaint of post-menopausal bleeding for 1&#xa0;month. On radiology, a mass lesion was noted in anterior myometrium with increased endometrial thickness. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was done. On histology, diagnosis of endometrioid carcinoma, NOS with myometrial invasion up to 2&#xa0;mm, FIGO grade 2 with a submucosal lipoleiomyoma was made. At the 4&#xa0;months of follow-up patient is asymptomatic and doing her routine work. LL is a rare fat containing variant of a common benign tumor of the uterus. Submucosal LL, if associated with endometrial malignancy, may result in misdiagnosis.</p>

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Uterine Submucosal Lipoleiomyoma Co-existing with Endometrioid Carcinoma: An Interesting Case Report

  • 期刊论文

  • 发表日期：

    2025年5月5日

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  • Rakesh Kumar Gupta,
  • Sarita Rajbhar,
  • Ashish Kumar Gupta

摘要

Lipoleiomyoma (LL) is a rare variant of leiomyoma comprising admixture of adipocytes and mature smooth muscle cells in variable proportion. It can be diagnosed as an incidental finding or occur in association with other common gynecological conditions driven by hyperestrogenic state like adenomyosis, endometrial polyp, endometrial hyperplasia and endometrial carcinoma. A pre-operative diagnosis is difficult due to overlapping features with other fat containing tumors. Herein, we report an interesting case of submucosal LL in association with endometrioid carcinoma in an elderly woman with the review of literature. A 69-year-old lady was presented with the complaint of post-menopausal bleeding for 1 month. On radiology, a mass lesion was noted in anterior myometrium with increased endometrial thickness. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was done. On histology, diagnosis of endometrioid carcinoma, NOS with myometrial invasion up to 2 mm, FIGO grade 2 with a submucosal lipoleiomyoma was made. At the 4 months of follow-up patient is asymptomatic and doing her routine work. LL is a rare fat containing variant of a common benign tumor of the uterus. Submucosal LL, if associated with endometrial malignancy, may result in misdiagnosis.