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<p>Conjunctival lymphomas are groups of rare ocular neoplasm; the majority of the reported cases are attributed to uncontrolled B-cell proliferation presenting with a wide range of typical and atypical presentations. The case report highlights the importance of thorough clinical examination and timely diagnosis in identifying such relatively indolent neoplasm in unusual sites and distinguishing them from its mimickers. Here, we report a case in a 50-year-old male patient who presented initially with symptoms of intermittent redness and irritation of the right eye for 7&#xa0;months. The patient was initially diagnosed as a case of conjunctivitis with exuberant papillary reaction in a peripheral heath center and treated with topical medical therapy and advised follow-up. The symptoms persisted, and hence, the patient was referred to a tertiary care center 2&#xa0;months after initial visit. Examination showed a salmon-pink fleshy mass in the conjunctiva extending to the fornix. Histopathology supplemented by immunohistochemistry findings showed features suggestive of extra nodal marginal zone B-cell non-Hodgkin’s lymphoma. The patient was treated with external beam radiotherapy and was asymptomatic 6&#xa0;months posttreatment. Conjunctival lymphomas albeit rare may be difficult to diagnose without clinical and histopathological findings, lymphoma masquerading conjunctivitis is extremely rare, and the reported case highlights the unique presentation.</p>

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Primary Conjunctival Lymphoma Presenting as Conjunctivitis: A Case Report

  • 期刊论文

  • 发表日期：

    2025年5月6日

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  • Pranjal Kalita,
  • Biswajit Dey,
  • Vandana Raphael,
  • Tanie Natung,
  • Sumit Kumar

摘要

Conjunctival lymphomas are groups of rare ocular neoplasm; the majority of the reported cases are attributed to uncontrolled B-cell proliferation presenting with a wide range of typical and atypical presentations. The case report highlights the importance of thorough clinical examination and timely diagnosis in identifying such relatively indolent neoplasm in unusual sites and distinguishing them from its mimickers. Here, we report a case in a 50-year-old male patient who presented initially with symptoms of intermittent redness and irritation of the right eye for 7 months. The patient was initially diagnosed as a case of conjunctivitis with exuberant papillary reaction in a peripheral heath center and treated with topical medical therapy and advised follow-up. The symptoms persisted, and hence, the patient was referred to a tertiary care center 2 months after initial visit. Examination showed a salmon-pink fleshy mass in the conjunctiva extending to the fornix. Histopathology supplemented by immunohistochemistry findings showed features suggestive of extra nodal marginal zone B-cell non-Hodgkin’s lymphoma. The patient was treated with external beam radiotherapy and was asymptomatic 6 months posttreatment. Conjunctival lymphomas albeit rare may be difficult to diagnose without clinical and histopathological findings, lymphoma masquerading conjunctivitis is extremely rare, and the reported case highlights the unique presentation.