Scholarlink

<p>A leaky gut is implicated in reduced sarcopenia-related quality of life (SarQoL). Angiotensin receptor blockers (ARBs) demonstrate anti-sarcopenic potential. However, their effects on SarQoL and relevant contributions to intestinal leak in chronic kidney disease (CKD) patients are unknown. We recruited older adult men, including controls (<i>n</i> = 66) and CKD patients categorized into non-ARB (<i>n</i> = 72) and ARB (<i>n</i> = 59) groups. We measured plasma zonulin and Lipopolysaccharides binding protein (LBP) as markers of intestinal leak, SarQoL, and sarcopenia markers of handgrip strength (HGS), skeletal mass index (SMI), and gait speed. All measurements were taken at baseline and 16&#xa0;weeks. ARBs improved the SarQoL scores for physical and mental health, body composition, and activities of daily living, along with total SarQoL scores compared to baseline (all <i>p</i> &lt; 0.05). ARBs also reduced plasma zonulin and LBP levels, which were not observed in the non-ARB group. We found significant dynamic correlations of reduction in plasma zonulin and LBP with improvement in total SarQoL scores in the ARB group (all <i>p</i> &lt; 0.05). Lastly, ARBs also improved HGS and gait speed and reduced plasma C-reactive proteins (all <i>p</i> &lt; 0.05). Collectively, we report an ARB-mediated improvement in SarQoL in CKD patients, which may partly involve the repair of intestinal leaks. Further studies are warranted to investigate individual bacteria and bacterial products mediating the positive effects of ARBs on SarQoL in CKD patients.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Angiotensin Receptor Blockers Improve Sarcopenia-related Quality of Life by Repairing Intestinal Leak in Patients with Chronic Kidney Disease

  • 期刊论文

  • 发表日期：

    2025年4月24日

查看全文
  • Rizwan Qaisar,
  • Ayousha Burki,
  • Asima Karim,
  • Shahjahan Ustrana,
  • Firdos Ahmad

摘要

A leaky gut is implicated in reduced sarcopenia-related quality of life (SarQoL). Angiotensin receptor blockers (ARBs) demonstrate anti-sarcopenic potential. However, their effects on SarQoL and relevant contributions to intestinal leak in chronic kidney disease (CKD) patients are unknown. We recruited older adult men, including controls (n = 66) and CKD patients categorized into non-ARB (n = 72) and ARB (n = 59) groups. We measured plasma zonulin and Lipopolysaccharides binding protein (LBP) as markers of intestinal leak, SarQoL, and sarcopenia markers of handgrip strength (HGS), skeletal mass index (SMI), and gait speed. All measurements were taken at baseline and 16 weeks. ARBs improved the SarQoL scores for physical and mental health, body composition, and activities of daily living, along with total SarQoL scores compared to baseline (all p < 0.05). ARBs also reduced plasma zonulin and LBP levels, which were not observed in the non-ARB group. We found significant dynamic correlations of reduction in plasma zonulin and LBP with improvement in total SarQoL scores in the ARB group (all p < 0.05). Lastly, ARBs also improved HGS and gait speed and reduced plasma C-reactive proteins (all p < 0.05). Collectively, we report an ARB-mediated improvement in SarQoL in CKD patients, which may partly involve the repair of intestinal leaks. Further studies are warranted to investigate individual bacteria and bacterial products mediating the positive effects of ARBs on SarQoL in CKD patients.