<p>Mental disorders, including substance-related disorders, are among the most significant contributors to workplace absenteeism, presenteeism, and disability costs to employers. As such, employers are commonly interested in workplace health promotion interventions to help employees stay mentally healthy and productive. This perspective paper examines the effectiveness of health promotion interventions used in the workplace and provides recommendations. We performed a literature search with a focus on systematic reviews on workplace health promotion programs for mental health and their effectiveness. Worker-directed interventions provide knowledge and skills to help employees stay mentally healthy and develop resilience. Work-directed interventions recognize that the workplace can be a significant mental health risk, and they involve organizational changes to reduce job stressors. Systematic analyses of worker and work-directed intervention types conclude that they can provide minor health benefits, but the evidence collected is insufficient to make generalizable recommendations. Although the literature is unable to provide simple, universal solutions to the question of effective health interventions in the workplace, it provides recommendations to improve success rates. Job stressors and resulting mental health outcomes are context-specific, so workplace health promotion interventions should be tailored to the specific workplace context. A combination of worker- and work-directed interventions that aim to protect and promote mental health and help employees facing mental health challenges should be considered. Ideally, interventions should be created collaboratively by employees and leadership. Proper planning, implementation, and evaluation are also essential, as well as support from the surrounding cultural, social, community, and governmental environment.</p>