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<p>Retinopathy of prematurity (ROP) is one of the leading causes of childhood blindness. ROP is frequently observed in infants with patent ductus arteriosus (PDA). Little is known about disease-related risk factors in very low birth weight infants (VLBW) especially those associated with incidence of ROP among VLBW infants with PDA. The objective of this study is to determine if severe PDA is a risk factor for clinically significant ROP in VLBW infants. We performed a single-institution retrospective case–control study of VLBW pre-term infants born at a gestational age of ≤ 32&#xa0;weeks. The sample included 90 neonates diagnosed with PDA between 2006 and 2014. Cases were identified as infants who developed clinically significant ROP (ROP stage ≥ 2). We further diagnosed infants with severe PDA if they required medical or surgical intervention to induce PDA closure. We employed logistic regression analysis to compute adjusted odds ratios (ORs). Forty-two infants (46%) were diagnosed with clinically significant ROP and 50 (55%) were identified as severe PDA cases. Within our adjusted model, an association between PDA severity and clinically significant ROP was observed (OR: 32.05, 95% CI 3.45–297.94). Further, our model also demonstrated a clinically significant ROP—yielding an area under receiver operating characteristic (ROC) curve of 95.6% (95% CI 90.9–100%). Our study suggests that severe PDA is an independent risk factor for clinically significant ROP in VLBW infants with PDA. However, a study able to utilize a larger data set is required to confirm our findings.</p>

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Severe Patent Ductus Arteriosus Is a Risk Factor for Clinically Significant Retinopathy of Prematurity in Very Low Birth Weight Infants

  • 期刊论文

  • 发表日期：

    2025年3月14日

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  • Ramdeepak Hari,
  • Pranav Mellacheruvu,
  • Opara Chibuzor Nonye,
  • Alok Rastogi,
  • Janardhan Mydam

摘要

Retinopathy of prematurity (ROP) is one of the leading causes of childhood blindness. ROP is frequently observed in infants with patent ductus arteriosus (PDA). Little is known about disease-related risk factors in very low birth weight infants (VLBW) especially those associated with incidence of ROP among VLBW infants with PDA. The objective of this study is to determine if severe PDA is a risk factor for clinically significant ROP in VLBW infants. We performed a single-institution retrospective case–control study of VLBW pre-term infants born at a gestational age of ≤ 32 weeks. The sample included 90 neonates diagnosed with PDA between 2006 and 2014. Cases were identified as infants who developed clinically significant ROP (ROP stage ≥ 2). We further diagnosed infants with severe PDA if they required medical or surgical intervention to induce PDA closure. We employed logistic regression analysis to compute adjusted odds ratios (ORs). Forty-two infants (46%) were diagnosed with clinically significant ROP and 50 (55%) were identified as severe PDA cases. Within our adjusted model, an association between PDA severity and clinically significant ROP was observed (OR: 32.05, 95% CI 3.45–297.94). Further, our model also demonstrated a clinically significant ROP—yielding an area under receiver operating characteristic (ROC) curve of 95.6% (95% CI 90.9–100%). Our study suggests that severe PDA is an independent risk factor for clinically significant ROP in VLBW infants with PDA. However, a study able to utilize a larger data set is required to confirm our findings.