<p>The purpose of this study was to (a) describe peer victimization profiles based on levels of overt and relational victimization, aggression, and defending, (b) examine demographic predictors of profile membership, and (c) assess differences between profiles in perceived social support and internalizing symptoms. Data were derived from 1539 adolescent students (girls <i>n</i> = 835, boys <i>n</i> = 704) who ranged in age from 14 to 17&#xa0;years (<i>M</i> = 15.50, <i>SD</i> = 1.15). Participants reported on overt and relational peer victimization, aggression, and defending behaviors, along with friend and parent support, and anxiety and depression symptoms. Latent profile analysis provided evidence for six profiles: <i>average victimization and aggression</i> (44%), <i>average involvement</i> (22%), <i>average defending-low victimization and aggression</i> (11%), <i>low involvement</i> (8%), <i>high victimization and aggression-average defending</i> (8%), and <i>high defending-average victimization and aggression</i> (7%). Multinomial logistic regression showed there were meaningful individual differences in profile membership based on participants’ demographic characteristics (i.e., gender, sexual orientation, disability status, free or reduced-price lunch). Students classified in the <i>average victimization and aggression</i> and <i>high victimization and aggression-average defending</i> profiles consistently reported the lowest levels of social support and the highest levels of anxiety and depression symptoms. Results illustrate unique combinations of peer victimization involvement roles and suggest these patterns are meaningfully tied to students’ social support and internalizing symptoms.</p>