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<p>Dielectrophoresis (DEP) refers to an electrokinetic phenomenon where a force acts upon a dielectric particle when placed in a non-uniform electric field. The objective of this work is to model a DEP-type microseparator aimed at separating platelets from Red Blood Cells (RBCs). A newly developed microfluidic apparatus featuring focuser and separator electrodes working at a low voltage and a frequency of 100&#xa0;kHz is suggested for the specific task of platelets and RBCs separation. The employment of a low voltage level guarantees the maintenance of the vitality of biological cells, a critical aspect in medical contexts. The electric potential, electric field, velocity, pressure, and DEP force profiles on two particles are displayed through simulation. By means of a comparative analysis conducted using the finite element method, we illustrate the repercussions of adjusting the input voltage applied to the electrodes on the efficient separation of particles. It is envisioned that such a comprehensive design is well-suited for the achievement of DEP-based practical cell separation biochips.</p>

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An Electrokinetic-Based Microfluidic Separator Having Focuser Electrodes for Blood Cells Separation

  • 期刊论文

  • 发表日期：

    2025年7月2日

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  • Elnaz. Poorreza

摘要

Dielectrophoresis (DEP) refers to an electrokinetic phenomenon where a force acts upon a dielectric particle when placed in a non-uniform electric field. The objective of this work is to model a DEP-type microseparator aimed at separating platelets from Red Blood Cells (RBCs). A newly developed microfluidic apparatus featuring focuser and separator electrodes working at a low voltage and a frequency of 100 kHz is suggested for the specific task of platelets and RBCs separation. The employment of a low voltage level guarantees the maintenance of the vitality of biological cells, a critical aspect in medical contexts. The electric potential, electric field, velocity, pressure, and DEP force profiles on two particles are displayed through simulation. By means of a comparative analysis conducted using the finite element method, we illustrate the repercussions of adjusting the input voltage applied to the electrodes on the efficient separation of particles. It is envisioned that such a comprehensive design is well-suited for the achievement of DEP-based practical cell separation biochips.