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<p>A Schiff base ligand (L) was used as primary ligand and potassium anthranilate (Anth) was used as the secondary ligand in the molar ratio M: L:2Anth to synthesize a new platinum(IV) mixed-ligand complex [Pt(L)(Anth)₂]Cl₂. The Schiff base ligand was synthesized by the condensation of 4-Aminoantipyrine with 4-Hydroxybenzaldehyde and was verified as a bidentate ligand. The UV-visible, FT-IR, 1&#xa0;H NMR, 13&#xa0;C NMR, CHN elemental analysis, molar conductance, chloride ion determination and melting point measurements were used to characterize the ligand and the complex. The results of the molar conductance showed that the electrolytic behavior was 1:2, where the two chloride ions were present outside the coordination sphere, while the spectroscopic and analytical results supported octahedral geometry of the Pt(IV) center. The synthesized complex showed better antimicrobial and cytotoxic activity than the free ligand. Moreover, the molecular docking and SwissADME analyses were in accordance with the experimental results, demonstrating good binding affinity and favorable physicochemical properties. The synthesized Pt(IV) complex exhibited promising biological activities, including cytotoxic activity against breast cancer cells, antibacterial activity, and antioxidant potential, indicating that it represents a promising scaffold for further pharmacological and biological investigations.</p>

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Structural Characterization and Biological Assessment of Platinum(IV) Schiff Base Mixed-Ligand Complex with Anthranilic Acid

  • 期刊论文

  • 发表日期：

    2026年7月28日

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  • Saja Ahmed,
  • Maysam Basem Abdulsalam,
  • Salam R. AL-Ayash,
  • Taghreed Hashim Al-Noor,
  • Mohanad Mousa Kareem

摘要

A Schiff base ligand (L) was used as primary ligand and potassium anthranilate (Anth) was used as the secondary ligand in the molar ratio M: L:2Anth to synthesize a new platinum(IV) mixed-ligand complex [Pt(L)(Anth)₂]Cl₂. The Schiff base ligand was synthesized by the condensation of 4-Aminoantipyrine with 4-Hydroxybenzaldehyde and was verified as a bidentate ligand. The UV-visible, FT-IR, 1 H NMR, 13 C NMR, CHN elemental analysis, molar conductance, chloride ion determination and melting point measurements were used to characterize the ligand and the complex. The results of the molar conductance showed that the electrolytic behavior was 1:2, where the two chloride ions were present outside the coordination sphere, while the spectroscopic and analytical results supported octahedral geometry of the Pt(IV) center. The synthesized complex showed better antimicrobial and cytotoxic activity than the free ligand. Moreover, the molecular docking and SwissADME analyses were in accordance with the experimental results, demonstrating good binding affinity and favorable physicochemical properties. The synthesized Pt(IV) complex exhibited promising biological activities, including cytotoxic activity against breast cancer cells, antibacterial activity, and antioxidant potential, indicating that it represents a promising scaffold for further pharmacological and biological investigations.