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<p>Olive mill wastewater (OMWW) represents a major agro-industrial by-product rich in bioactive phenolic compounds, mainly hydroxytyrosol. This study aimed to valorize olive mill wastewater by extracting its antioxidant compounds and formulating them into a stable cream. The olive mill wastewater extract was obtained through liquid-liquid extraction with ethyl acetate and characterized by HPLC-DAD and LC-ESI-MS/MS. Phenolic and flavonoid contents were determined, and the antioxidant potential was evaluated using DPPH, TAC, and FRAP assays. To better understand the molecular basis of this activity, a docking study was performed on hydroxytyrosol, the major constituent in the olive mill wastewater extract according to HPLC-DAD analysis performed at 254&#xa0;nm and 280&#xa0;nm. Then, the extract was evaluated for its antibacterial activity against various bacterial strains. Multiple oils in water emulsions were formulated to optimize the most stable formula. The olive mill wastewater extract demonstrated pronounced antioxidant and antibacterial activities. The formulated cream went through rigorous evaluation of its stability, homogeneity, rheo-fluidifying properties, and microbiological safety, confirming its enhanced performance and suitability for cosmetic applications. The resulting cream showed promising cosmetic properties for skin protection and antioxidant effects, supporting the sustainable valorization of olive by-products in the cosmetic industry.</p>

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Protective Cream Against Oxidative Stress Enriched with Bioactive Compounds from Olive Mill Wastewater

  • 期刊论文

  • 发表日期：

    2026年6月20日

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  • Zouhour Abdellaoui,
  • Raoudha Ben Ameur,
  • Lilia Fourati,
  • Siwar Soltani,
  • Mohamed Chamkha,
  • Sami Sayadi,
  • Noureddine Allouche

摘要

Olive mill wastewater (OMWW) represents a major agro-industrial by-product rich in bioactive phenolic compounds, mainly hydroxytyrosol. This study aimed to valorize olive mill wastewater by extracting its antioxidant compounds and formulating them into a stable cream. The olive mill wastewater extract was obtained through liquid-liquid extraction with ethyl acetate and characterized by HPLC-DAD and LC-ESI-MS/MS. Phenolic and flavonoid contents were determined, and the antioxidant potential was evaluated using DPPH, TAC, and FRAP assays. To better understand the molecular basis of this activity, a docking study was performed on hydroxytyrosol, the major constituent in the olive mill wastewater extract according to HPLC-DAD analysis performed at 254 nm and 280 nm. Then, the extract was evaluated for its antibacterial activity against various bacterial strains. Multiple oils in water emulsions were formulated to optimize the most stable formula. The olive mill wastewater extract demonstrated pronounced antioxidant and antibacterial activities. The formulated cream went through rigorous evaluation of its stability, homogeneity, rheo-fluidifying properties, and microbiological safety, confirming its enhanced performance and suitability for cosmetic applications. The resulting cream showed promising cosmetic properties for skin protection and antioxidant effects, supporting the sustainable valorization of olive by-products in the cosmetic industry.