Recent Explorations in the Genus Distichochlamys as an Emerging Source of Bioactive Phytochemicals: From Folk Medicine to Modern Pharmacology
摘要
The members of the genus Distichochlamys M.F. Newman (Zingiberaceae) are herb-forming plants, traditionally used as culinary spices and in folk medicine to manage diabetes and infection-related diseases. Recent investigations on the phytocompounds and biological activities of Distichochlamys species have been reported. However, comprehensive articles on emerging spice plants of this genus are still scarce. This study explores the diverse phytoconstituents of the emerging spice plants from the genus Distichochlamys and discusses their potential pharmacological effects. A literature survey was conducted using scientific databases, including Web of Science, PubMed, Scopus, Google Scholar, and ethnobotanical textbooks. Clustering analysis was performed using the Unweighted Pair Group Method with Arithmetic Mean to generate dendrograms based on the chemical composition of essential oils (EOs). Previous publications have revealed that EOs, amino acids, fatty acids, phenolics, flavonoids, coumaric acid derivatives, steroids, diterpenoids, and monoglycerides are found in various parts of Distichochlamys species. Among the EOs, eucalyptol, β-pinene, α-pinene, β-caryophyllene, β-elemene, α-citral, β-citral, α-terpineol, and geranyl acetate have been identified as predominant constituents in different plant parts. Moreover, modern pharmacological investigations have demonstrated that both crude extracts and isolated compounds exhibit diverse bioactivities, such as antioxidant, antimicrobial, antidiabetic, anti-inflammatory, antithrombotic, anti-Alzheimer’s, and mosquito larvicidal activities. Dendrogram analysis provides valuable insights into chemical similarities and differences among Distichochlamys species, revealing the influence of taxonomic relationships, geographic factors, and the plant parts used. This is the first literature review summarizing the phytochemical compounds, biological activities, and potential applications of Distichochlamys species in modern drug development.