Scholarlink

<p>Gold nanoparticles (AuNPs) were green-synthesized using aqueous leaf extracts of <i>Achyranthes aspera</i> and <i>Limonia acidissima</i>, which served as natural reducing and stabilizing agents. The formation and physicochemical properties of the biosynthesized PVP-capped AuNPs were confirmed by UV-visible spectroscopy, FTIR, XRD and HR-TEM analyses. Surface plasmon resonance bands were observed at 529&#xa0;nm and 544&#xa0;nm, confirming AuNP formation. XRD patterns revealed the characteristic face-centered cubic (FCC) crystalline structure of gold. HR-TEM analysis showed predominantly spherical nanoparticles with average particle sizes of 10.89 ± 1.05&#xa0;nm (<i>A. aspera</i>) and 18.89 ± 1.59&#xa0;nm (<i>L. acidissima</i>). Biological evaluation demonstrated significant antibacterial activity against <i>Staphylococcus aureus</i>,<i> Pseudomonas aeruginosa</i>,<i> Bacillus subtilis</i>, and <i>Escherichia coli</i>, with zones of inhibition ranging from 22 to 28&#xa0;mm. Furthermore, cytotoxicity studies against MCF-7 breast cancer cells revealed dose-dependent anticancer activity, with IC<sub>50</sub> values of 118&#xa0;µg/mL and 113&#xa0;µg/mL for <i>A. aspera</i>- and <i>L. acidissima</i>-derived AuNPs, respectively. This study aligns with the United Nations Sustainable Development Goals, particularly SDG 3 (Good Health and Well-Being) through the development of antibacterial and anticancer nanomaterials, and SDG 12 (Responsible Consumption and Production) by employing an eco-friendly, plant-mediated green synthesis approach.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Phytogenic Gold Nanoparticles Derived from Achyranthes aspera Linn and Limonia acidissima: Antimicrobial and Cytotoxic Insights

  • 期刊论文

  • 发表日期：

    2026年4月28日

查看全文
  • Kalrav Oza,
  • Praharsh Raj,
  • Chirag Makvana,
  • Vikram Panchal,
  • Manoj Vora

摘要

Gold nanoparticles (AuNPs) were green-synthesized using aqueous leaf extracts of Achyranthes aspera and Limonia acidissima, which served as natural reducing and stabilizing agents. The formation and physicochemical properties of the biosynthesized PVP-capped AuNPs were confirmed by UV-visible spectroscopy, FTIR, XRD and HR-TEM analyses. Surface plasmon resonance bands were observed at 529 nm and 544 nm, confirming AuNP formation. XRD patterns revealed the characteristic face-centered cubic (FCC) crystalline structure of gold. HR-TEM analysis showed predominantly spherical nanoparticles with average particle sizes of 10.89 ± 1.05 nm (A. aspera) and 18.89 ± 1.59 nm (L. acidissima). Biological evaluation demonstrated significant antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, and Escherichia coli, with zones of inhibition ranging from 22 to 28 mm. Furthermore, cytotoxicity studies against MCF-7 breast cancer cells revealed dose-dependent anticancer activity, with IC50 values of 118 µg/mL and 113 µg/mL for A. aspera- and L. acidissima-derived AuNPs, respectively. This study aligns with the United Nations Sustainable Development Goals, particularly SDG 3 (Good Health and Well-Being) through the development of antibacterial and anticancer nanomaterials, and SDG 12 (Responsible Consumption and Production) by employing an eco-friendly, plant-mediated green synthesis approach.

Graphical Abstract