A Sensitive Electroanalytical Approach for Aprepitant Quantification in Pharmaceutical Formulations and Urine Samples at A Boron-Doped Diamond Electrode: The Role of Anionic Surfactant Media
摘要
The purpose of this research is to explain the voltammetric evaluation of aprepitant (APT) using the boron-doped diamond (BDD) electrode with an anionic surfactant media. The APT was measured by cyclic voltammetry in a 0.1 mol L− 1 H2SO4 solution, revealing adsorption and diffusion-controlled processes. The oxidation peaks were well-defined at + 1.5 V (vs. Ag/AgCl). The addition of sodium dodecyl sulfate (an anionic surfactant) in the selected supporting electrolyte significantly increased the oxidation peak currents of APT. To determine APT in a 0.1 mol L− 1 H2SO4 solution, a linear relationship was observed under the optimized experimental conditions, including 1.0 × 10− 4 mol L− 1 SDS at an accumulation potential of + 1.5 V (vs. Ag/AgCl) for 30 s under open-circuit conditions. The linear concentration was discovered by applying 1.0 to 25.0 µg mL− 1 (1.87 × 10− 6 − 4.68 × 10− 5 mol L− 1) as well as the detection limit 0.19 µg mL− 1 (3.56 × 10− 7 mol L− 1). The established technology was successfully utilized to measure APT in pharmaceutical formulations and urine samples. Our research indicates that this is the first non-modified electroanalytical method for voltammetric APT detection to be identified.