Scholarlink

<p>We present the electrospun formation of curcumin-incorporated poly(lactic acid) (PLA)/poly(hydroxybutyrate) (PHB) nanofiber mat. The prepared mats were characterised for analytical, mechanical, and biological attributes. SEM analysis revealed bead-free uniform nanofiber texture with uneven orientations. The average diameter of the electrospun nanofibers ranged from 102 ± 20 to 195 ± 40&#xa0;nm, depending on composition. FTIR analysis revealed a shift in the C = O peak of PLA/PHB on curcumin inclusion, indicating molecular interactions among the precursors. PHB mediation made the PLA-based matrix more crystalline. PLA nanofiber mat demonstrated thermal stability up to 250 ± 10&#xa0;°C and degraded at 334 ± 10&#xa0;°C. On PHB inclusion (50 wt%), the corresponding values reduced to 194 ± 10&#xa0;°C and 290 ± 10&#xa0;°C; the curcumin-loaded PLA/PHB electrospun nanofiber mat, however, expressed them as 210 ± 10&#xa0;°C and 300 ± 10&#xa0;°C. The native PHB nanofiber mat showed a water contact angle (WCA) of 112.9 ± 2.0°, whereas PLA/PHB (50/50, wt%) showed a WCA of 102.3 ± 2.0°, i.e., in the hydrophobic range. In contrast, the curcumin-loaded PLA/PHB nanofiber mat exhibited hydrophilic behaviour, with a WCA of 81.4 ± 2.0°. The curcumin-loaded PLA/PHB nanofiber mat exhibited pH-dependent drug release, with the fastest (90%, at 24&#xa0;h) at pH 8.4. The release phenomena followed distinct models at different pH values, including Higuchi, first-order, and zero-order kinetics. The curcumin-mediated PLA/PHB nanofiber mat exhibited broad-spectrum antibacterial activity. It exhibited antioxidant activity of 85.6% and cell viability of 90.2%. The results were statistically analysed and demonstrated that the curcumin-loaded PLA/PHB electrospun nanofiber mat is an exceptional candidate for sustained drug delivery applications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Curcumin-loading of poly(lactic acid)/poly(hydroxybutyrate) co-electrospun Nanofibers for Potential Drug Delivery Applications

  • 期刊论文

  • 发表日期：

    2026年2月23日

查看全文
  • Zulfiqar Ali Raza,
  • Ayesha Arif

摘要

We present the electrospun formation of curcumin-incorporated poly(lactic acid) (PLA)/poly(hydroxybutyrate) (PHB) nanofiber mat. The prepared mats were characterised for analytical, mechanical, and biological attributes. SEM analysis revealed bead-free uniform nanofiber texture with uneven orientations. The average diameter of the electrospun nanofibers ranged from 102 ± 20 to 195 ± 40 nm, depending on composition. FTIR analysis revealed a shift in the C = O peak of PLA/PHB on curcumin inclusion, indicating molecular interactions among the precursors. PHB mediation made the PLA-based matrix more crystalline. PLA nanofiber mat demonstrated thermal stability up to 250 ± 10 °C and degraded at 334 ± 10 °C. On PHB inclusion (50 wt%), the corresponding values reduced to 194 ± 10 °C and 290 ± 10 °C; the curcumin-loaded PLA/PHB electrospun nanofiber mat, however, expressed them as 210 ± 10 °C and 300 ± 10 °C. The native PHB nanofiber mat showed a water contact angle (WCA) of 112.9 ± 2.0°, whereas PLA/PHB (50/50, wt%) showed a WCA of 102.3 ± 2.0°, i.e., in the hydrophobic range. In contrast, the curcumin-loaded PLA/PHB nanofiber mat exhibited hydrophilic behaviour, with a WCA of 81.4 ± 2.0°. The curcumin-loaded PLA/PHB nanofiber mat exhibited pH-dependent drug release, with the fastest (90%, at 24 h) at pH 8.4. The release phenomena followed distinct models at different pH values, including Higuchi, first-order, and zero-order kinetics. The curcumin-mediated PLA/PHB nanofiber mat exhibited broad-spectrum antibacterial activity. It exhibited antioxidant activity of 85.6% and cell viability of 90.2%. The results were statistically analysed and demonstrated that the curcumin-loaded PLA/PHB electrospun nanofiber mat is an exceptional candidate for sustained drug delivery applications.