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<p>This study investigates the antibacterial and anti-inflammatory potential of <i>Passiflora edulis</i> peel extract, aiming to valorize natural resources and highlight its therapeutic relevance. The extract was prepared using Ultrasound-Assisted extraction (UAE), and the bioactive compounds were identified by HPLC-DAD analysis. The antibacterial activity was evaluated using the agar well diffusion method against <i>Staphylococcus aureus</i>, <i>Bacillus cereus</i>, <i>Escherichia coli</i>, and <i>Salmonella typhimurium</i>. To further elucidate the mechanism of action, molecular docking studies were performed, providing insights into the interactions of bioactive phytochemicals with bacterial and inflammatory targets. Among the identified compounds, gallic acid, caffeic acid, coumaric acid, ferulic acid, rutin, luteolin-7-<i>O</i>-glucoside, and apigenin-7-<i>O</i>-glucoside showed high binding affinities and stable interactions, supporting their dual antibacterial and anti-inflammatory roles. Overall, these findings demonstrate that the peel extract of <i>Passiflora edulis</i> is a rich source of bioactive molecules, combining strong in vitro activity with computational evidence of molecular efficacy, highlighting its potential as a natural therapeutic agent.</p>

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Anti-Inflammatory and Antibacterial Activities with Molecular Docking Studies of Optimized Passion Fruit Extract

  • 期刊论文

  • 发表日期：

    2026年2月18日

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  • Zouhour Jebli,
  • Mabrouk Horchani,
  • Hichem Ben Jannet,
  • Ridha Ben Salem,
  • Ghayth Rigane

摘要

This study investigates the antibacterial and anti-inflammatory potential of Passiflora edulis peel extract, aiming to valorize natural resources and highlight its therapeutic relevance. The extract was prepared using Ultrasound-Assisted extraction (UAE), and the bioactive compounds were identified by HPLC-DAD analysis. The antibacterial activity was evaluated using the agar well diffusion method against Staphylococcus aureus, Bacillus cereus, Escherichia coli, and Salmonella typhimurium. To further elucidate the mechanism of action, molecular docking studies were performed, providing insights into the interactions of bioactive phytochemicals with bacterial and inflammatory targets. Among the identified compounds, gallic acid, caffeic acid, coumaric acid, ferulic acid, rutin, luteolin-7-O-glucoside, and apigenin-7-O-glucoside showed high binding affinities and stable interactions, supporting their dual antibacterial and anti-inflammatory roles. Overall, these findings demonstrate that the peel extract of Passiflora edulis is a rich source of bioactive molecules, combining strong in vitro activity with computational evidence of molecular efficacy, highlighting its potential as a natural therapeutic agent.