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<p>Molecularly imprinted polymers (MIPs) are gaining recognition as promising synthetic materials for the development of electrochemical biosensors due to their high selectivity and stability. The choice of monomeric materials is crucial as it impacts the sensitivity, reactivity, selectivity, conductivity and biocompatibility of biosensors developed from MIPs. The review highlighted the main factors for selecting functional monomers in MIP synthesis with consideration on various interactions between monomers with the template molecules, the ratio of monomers to templates, structural features, and polymerization conditions. The review covers the promising monomers like aniline, thiophene, pyrrole and dopamine due to their advantageous electrochemical characteristics and capacity to create stable recognition cavities. The paper discusses important computational techniques like density functional theory (DFT) and molecular dynamics (MD) that helps in rational selection of monomer and understand interaction modeling. Furthermore, for toxic or unstable analytes, dummy template approaches are discussed. The importance of biocompatibility and regulatory considerations, especially for wearable sensor applications, is also covered. A thorough approach for selecting monomers in MIP synthesis is presented in this paper to enhance the functionality and applicability of electrochemical biosensors.</p>

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Critical Criteria for Choosing Monomers for Synthesis of Molecular Imprinted Polymers: Application in Electrochemical Biosensor Development

  • 期刊论文

  • 发表日期：

    2026年2月2日

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  • Deepanmol Singh,
  • Akanksha Shrivastav,
  • Sapna Jain

摘要

Molecularly imprinted polymers (MIPs) are gaining recognition as promising synthetic materials for the development of electrochemical biosensors due to their high selectivity and stability. The choice of monomeric materials is crucial as it impacts the sensitivity, reactivity, selectivity, conductivity and biocompatibility of biosensors developed from MIPs. The review highlighted the main factors for selecting functional monomers in MIP synthesis with consideration on various interactions between monomers with the template molecules, the ratio of monomers to templates, structural features, and polymerization conditions. The review covers the promising monomers like aniline, thiophene, pyrrole and dopamine due to their advantageous electrochemical characteristics and capacity to create stable recognition cavities. The paper discusses important computational techniques like density functional theory (DFT) and molecular dynamics (MD) that helps in rational selection of monomer and understand interaction modeling. Furthermore, for toxic or unstable analytes, dummy template approaches are discussed. The importance of biocompatibility and regulatory considerations, especially for wearable sensor applications, is also covered. A thorough approach for selecting monomers in MIP synthesis is presented in this paper to enhance the functionality and applicability of electrochemical biosensors.