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<p>Green nanoparticle synthesis is an eco-friendly method that uses natural solvents, making it a better alternative to chemical and physical techniques. Zinc oxide nanostructures have gained significant research interest due to their multifunctional properties and diverse applications. However, the growing concerns regarding environmental impact have resulted in the development of eco-friendly processes for their production, further promoting sustainable practices in the field. This study aimed to create zinc oxide nanoparticles (ZnONPs) using a green method that utilized fruit of <i>Pyrus boissieriana</i> extract as an efficient reducing agent. Zinc oxide nanoparticles have proven useful in many inorganic applications, and crystallites of Zinc Oxide can be generated rapidly and safely through a straightforward and environmentally friendly process. The production and properties of ZnONPs were verified using various analytical techniques, including UV–Vis spectrophotometry, X-ray Diffraction (XRD), and scanning electron microscopy (SEM). Fourier-transform infrared spectroscopy was also used to identify the specific functional groups involved in the reduction, stabilization, and capping of the nanoparticles. Cytotoxicity against AGS cells was determined using the MTT assay in vitro. The synthesized zinc oxide nanoparticles were tested against various Gram ( +) and Gram (-) strains to assess their potential as anti-bacterial agents. The study confirms that zinc oxide nanoparticles can act as natural anti-microbial agents through green synthesis, making them a promising candidate for producing anti- microbial therapeutic drugs.</p>

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Green Synthesis of Zinc Oxide Nanoparticles (ZnONPs) using Pyrus boissieriana (TELEKA) Fruit Extracts: Characterization, Antibacterial and Cytotoxic Activities Against Gastric Cancer Cell Lines

  • 期刊论文

  • 发表日期：

    2025年10月28日

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  • Parastoo Hashemi,
  • Shima joneidi,
  • Amin Barani,
  • Zahra Hashemi,
  • Mohammad Ali Ebrahimzadeh,
  • Parnia Hashemi

摘要

Green nanoparticle synthesis is an eco-friendly method that uses natural solvents, making it a better alternative to chemical and physical techniques. Zinc oxide nanostructures have gained significant research interest due to their multifunctional properties and diverse applications. However, the growing concerns regarding environmental impact have resulted in the development of eco-friendly processes for their production, further promoting sustainable practices in the field. This study aimed to create zinc oxide nanoparticles (ZnONPs) using a green method that utilized fruit of Pyrus boissieriana extract as an efficient reducing agent. Zinc oxide nanoparticles have proven useful in many inorganic applications, and crystallites of Zinc Oxide can be generated rapidly and safely through a straightforward and environmentally friendly process. The production and properties of ZnONPs were verified using various analytical techniques, including UV–Vis spectrophotometry, X-ray Diffraction (XRD), and scanning electron microscopy (SEM). Fourier-transform infrared spectroscopy was also used to identify the specific functional groups involved in the reduction, stabilization, and capping of the nanoparticles. Cytotoxicity against AGS cells was determined using the MTT assay in vitro. The synthesized zinc oxide nanoparticles were tested against various Gram ( +) and Gram (-) strains to assess their potential as anti-bacterial agents. The study confirms that zinc oxide nanoparticles can act as natural anti-microbial agents through green synthesis, making them a promising candidate for producing anti- microbial therapeutic drugs.