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<p>Chemical investigation of the methylene chloride and ethyl acetate soluble fractions of the alcoholic extract of <i>Kalanchoe thyrsiflora</i> fresh leaves led to the isolation and identification of two glyceryl fatty acid monoesters: glyceryl monostearate [1] and glyceryl monopalmitate [2]; one phenolic compound: gallic acid [3]; one flavonoid aglycone: isorhamnetin [4]; and one flavonoid glycoside: isorhamnetin-3-<i>O</i>-<i>β</i>-D-glucopyranoside [5]. Their structures were established by the means of <sup>1</sup>H and <sup>13</sup>C-NMR, MS, and other spectroscopic techniques. Compounds <b>1</b>, <b>2</b>, and <b>5</b> were isolated for the first time from the genus <i>Kalanchoe</i>. The cytotoxicity of the alcoholic extract was screened against <i>A-549</i>, <i>PC-</i>3, <i>HeLa</i>, and <i>CACO-2</i> tumor cells. Significant activity was observed against <i>A-549</i> cells. Further cytotoxicity evaluation of different fractions against <i>A-549</i> cells revealed that both hexane and methylene chloride fractions showed good activity.</p>

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Constituents’ Characterization and Cytotoxicity of Alcoholic Extract as well as Different Fractions of Kalanchoe thyrsiflora Fresh Leaves against A-549 Lung Cell Line

  • 期刊论文

  • 发表日期：

    2025年11月18日

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  • Nesma Nagah,
  • Marwa S. Abu Bakr,
  • Amany M. Korkor,
  • Ehab A. Ragab,
  • Mona H. Hetta,
  • Abd El-Salam I. Mohammed

摘要

Chemical investigation of the methylene chloride and ethyl acetate soluble fractions of the alcoholic extract of Kalanchoe thyrsiflora fresh leaves led to the isolation and identification of two glyceryl fatty acid monoesters: glyceryl monostearate [1] and glyceryl monopalmitate [2]; one phenolic compound: gallic acid [3]; one flavonoid aglycone: isorhamnetin [4]; and one flavonoid glycoside: isorhamnetin-3-O-β-D-glucopyranoside [5]. Their structures were established by the means of 1H and 13C-NMR, MS, and other spectroscopic techniques. Compounds 1, 2, and 5 were isolated for the first time from the genus Kalanchoe. The cytotoxicity of the alcoholic extract was screened against A-549, PC-3, HeLa, and CACO-2 tumor cells. Significant activity was observed against A-549 cells. Further cytotoxicity evaluation of different fractions against A-549 cells revealed that both hexane and methylene chloride fractions showed good activity.