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<p>Platinum in bivalent state has been determined using a quick, precise, accurate, and sensitive spectrophotometric approach based on its color reaction with 3-hydroxy-2-(2’-thienyl)-4-oxo-4<i>H</i>-1- benzopyran (HTC) in weakly basic medium producing bis ((4-oxo-2-(2’-thienyl)-4<i>H-chromen-3-yl)oxy)</i>platinum(II) [Pt(II)- HTC] complex. The stable (&gt; 96&#xa0;h) dark yellow species emerged right away from the dichloromethane extraction. The compound has a maximum absorption wavelength range of 405–430&#xa0;nm in sodium bicarbonate. The Pt(II)- HTC complex attains linearity in the range 0.0–0.6&#xa0;µg mL<sup>− 1</sup> with an ideal concentration range between 0.15 and 0.58&#xa0;µg mL<sup>− 1</sup>. The prepared complex was a highly sensitive binary system with a molar absorption coefficient of 1.112 × 10<sup>5</sup> L mol<sup>− 1</sup> cm<sup>− 1</sup> and Sandell’s sensitivity, 0.00175&#xa0;µg cm<sup>− 2</sup>. Using Job’s method of continuous variations and the mole ratio method, the stoichiometry, 1:2 [Pt(II): HTC] was affirmed. The calculated statistical parameters were: standard deviation (± 0.0067) and a % RSD (0.024). Furthermore, the related electrical properties of the examined complex were validated by the computational technique using a DFT approach. Different alloy samples were tested for their respective platinum content to corroborate analytical potency of the new complex. Also, the complex’s antimicrobial, anticancer, DNA photocleavage, and antioxidant properties are evaluated using the Agar diffusion assay, MTT Assay, Gel electrophoresis, and DPPH Radical scavenging methods, respectively. Data from the aforementioned experiments suggests that the investigated complex has a great deal of biological potential and hence can effectually be used in medicinal world.</p> Graphical Abstract <p></p>

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Synthesis, Spectroscopic and DFT Study of Pt(II)-3-hydroxy-2-(2’-thienyl)-4-oxo-4H-benzopyran Complex for Analytical and Biological Uses

  • 期刊论文

  • 发表日期：

    2025年8月28日

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  • Khushboo Devi,
  • Nivedita Agnihotri,
  • Gulshan Kumar,
  • Divya Mittal,
  • Omkar Bains,
  • Raj Kamal

摘要

Platinum in bivalent state has been determined using a quick, precise, accurate, and sensitive spectrophotometric approach based on its color reaction with 3-hydroxy-2-(2’-thienyl)-4-oxo-4H-1- benzopyran (HTC) in weakly basic medium producing bis ((4-oxo-2-(2’-thienyl)-4H-chromen-3-yl)oxy)platinum(II) [Pt(II)- HTC] complex. The stable (> 96 h) dark yellow species emerged right away from the dichloromethane extraction. The compound has a maximum absorption wavelength range of 405–430 nm in sodium bicarbonate. The Pt(II)- HTC complex attains linearity in the range 0.0–0.6 µg mL− 1 with an ideal concentration range between 0.15 and 0.58 µg mL− 1. The prepared complex was a highly sensitive binary system with a molar absorption coefficient of 1.112 × 105 L mol− 1 cm− 1 and Sandell’s sensitivity, 0.00175 µg cm− 2. Using Job’s method of continuous variations and the mole ratio method, the stoichiometry, 1:2 [Pt(II): HTC] was affirmed. The calculated statistical parameters were: standard deviation (± 0.0067) and a % RSD (0.024). Furthermore, the related electrical properties of the examined complex were validated by the computational technique using a DFT approach. Different alloy samples were tested for their respective platinum content to corroborate analytical potency of the new complex. Also, the complex’s antimicrobial, anticancer, DNA photocleavage, and antioxidant properties are evaluated using the Agar diffusion assay, MTT Assay, Gel electrophoresis, and DPPH Radical scavenging methods, respectively. Data from the aforementioned experiments suggests that the investigated complex has a great deal of biological potential and hence can effectually be used in medicinal world.

Graphical Abstract