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<p>Seaweeds are among the most promising plants recognized for their significant biological activities across various fields, especially in therapeutics. Phaeophyta (brown algae) are well-known for their beneficial biological properties. The methanolic extract <i>of Hormophysa triquetra</i> (HTE) was studied in vitro for its wound healing (WH) capabilities, demonstrating remarkable healing results of 78% and 97.48% after 24 and 48&#xa0;h, respectively. It also exhibited antidiabetic effects through enzyme activities, showing an activity level of 77.82% with an IC<sub>50</sub> of 146.44&#xa0;µg/mL, and 74.17% with an IC<sub>50</sub> of 159.82&#xa0;µg/mL, respectively. Additionally, anti-inflammatory effects were observed by investigating COX-1 activity, revealing the highest inhibitory activity at 71.29% with an IC<sub>50</sub> of 240.39&#xa0;µg/mL. Antimicrobial activities were evaluated against <i>Staphylococcus aureus</i>, <i>Enterococcus faecalis</i> ATCC, <i>Salmonella typhimurium</i> CRMB 006 (1) ATCC, <i>Pseudomonas aeruginosa</i> ATCC, <i>Aspergillus fumigatus</i> RCMB, and <i>Candida albicans</i> RCMB (1) ATCC using the disc diffusion method, noting significant antimicrobial activity against the tested strains, except for <i>A. fumigatus</i> and <i>C. albicans</i>. HTE showed moderate antiviral activity (++) with 38.27% inhibition against HSV-2 and a selectivity index (SI) ≥ 2, indicating that HTE exhibited antiviral activity that outweighed its toxicity. GC-MS analysis identified the presence of fatty acids, phenolics, flavonoids, terpenoids, ketones, esters, ethers, steroids, and more. In conclusion, the methanolic extract of <i>H. triquetra</i> demonstrated effective wound healing, antidiabetic, anti-inflammatory, antibacterial, and antiviral activities, suggesting its potential for future application in nutritional, pharmaceutical, and medicinal sectors.</p>

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In Vitro Assessment of Wound Healing, Antidiabetic, Anti-Inflammatory, Antimicrobial, and Antiviral Activities of Hormophysa triquetra (Phaeophyceae) Methanolic Extract

  • 期刊论文

  • 发表日期：

    2025年8月11日

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  • Suzan I. Ahmed,
  • Mostafa M. El-Sheekh,
  • Mofida E. M. Makhlof,
  • Faiza M. A. Akl

摘要

Seaweeds are among the most promising plants recognized for their significant biological activities across various fields, especially in therapeutics. Phaeophyta (brown algae) are well-known for their beneficial biological properties. The methanolic extract of Hormophysa triquetra (HTE) was studied in vitro for its wound healing (WH) capabilities, demonstrating remarkable healing results of 78% and 97.48% after 24 and 48 h, respectively. It also exhibited antidiabetic effects through enzyme activities, showing an activity level of 77.82% with an IC50 of 146.44 µg/mL, and 74.17% with an IC50 of 159.82 µg/mL, respectively. Additionally, anti-inflammatory effects were observed by investigating COX-1 activity, revealing the highest inhibitory activity at 71.29% with an IC50 of 240.39 µg/mL. Antimicrobial activities were evaluated against Staphylococcus aureus, Enterococcus faecalis ATCC, Salmonella typhimurium CRMB 006 (1) ATCC, Pseudomonas aeruginosa ATCC, Aspergillus fumigatus RCMB, and Candida albicans RCMB (1) ATCC using the disc diffusion method, noting significant antimicrobial activity against the tested strains, except for A. fumigatus and C. albicans. HTE showed moderate antiviral activity (++) with 38.27% inhibition against HSV-2 and a selectivity index (SI) ≥ 2, indicating that HTE exhibited antiviral activity that outweighed its toxicity. GC-MS analysis identified the presence of fatty acids, phenolics, flavonoids, terpenoids, ketones, esters, ethers, steroids, and more. In conclusion, the methanolic extract of H. triquetra demonstrated effective wound healing, antidiabetic, anti-inflammatory, antibacterial, and antiviral activities, suggesting its potential for future application in nutritional, pharmaceutical, and medicinal sectors.