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<p>The present work describes an efficient, cost-effective; Eco-friendly Knoevenagel condensation reaction using more economically viable <i>N</i>-Methylmorpholine as organocatalyst under simple conditions. Stereospecific Knoevenagel condensation reaction was studied with a wide range of aromatic aldehydes with active methylene reagents (malononitrile, ethylcyanoacetate) in water at room temperature with excellent E-factor, Rapid reaction times (2–4&#xa0;min), excellent yields (&gt; 95%), avoiding of chromatographic purification. Recovery and recycling of nitrogen based catalyst reinforce our method as an environmentally benign and energy efficient protocol and it may open up the path for conservative industrial production.</p> Graphical Abstract <p></p>

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Highly Practical Metal-Free Organocatalytic Aqueous Phase Knoevenagel Condensation Reaction at Ambient Temperature with Good E-Factor

  • 期刊论文

  • 发表日期：

    2025年3月5日

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  • Swathi Thangalipalli,
  • Siddarama Goud Bandalla,
  • Srikanth Kairoju,
  • Chandra Kiran Neella

摘要

The present work describes an efficient, cost-effective; Eco-friendly Knoevenagel condensation reaction using more economically viable N-Methylmorpholine as organocatalyst under simple conditions. Stereospecific Knoevenagel condensation reaction was studied with a wide range of aromatic aldehydes with active methylene reagents (malononitrile, ethylcyanoacetate) in water at room temperature with excellent E-factor, Rapid reaction times (2–4 min), excellent yields (> 95%), avoiding of chromatographic purification. Recovery and recycling of nitrogen based catalyst reinforce our method as an environmentally benign and energy efficient protocol and it may open up the path for conservative industrial production.

Graphical Abstract