<p>With recent advancements in green chemistry and the growing interest among researchers in reducing the risks associated with material toxicity, high costs, and complex preparation methods in the production of chemicals, pharmaceuticals, and other compounds and minerals, there has been an increasing demand for environmentally friendly, recoverable, and reusable catalysts. These challenges have led researchers to focus on developing sustainable and eco-friendly magnetic nanocatalyst that align with the principles of green chemistry. Among these catalysts, ferrite minerals containing spinels, especially magnesium ferrite, offer numerous advantages such as easy availability, low cost, a relatively simple preparation process, and the ability to be recovery using an external magnet. These factors motivated us to review the use of magnesium ferrite (MgFe₂O₄) as an effective catalyst in the preparation of certain heterocyclic compounds. In short, this study explores the latest developments related to the use of MgFe₂O₄ as a catalyst in the synthesis of pharmaceutical compounds within a one-pot multi-component reaction.</p>