<p>The Metal-Organic framework is an engineering material which offers an advanced perception of the progress of Science &amp; Technology in this millennium. MOFs are the self-assembled matrix of organic templates in the inorganic network with polynuclear secondary building blocks and miniature cages arising due to metal nodes and organic structures to begin porous periodicity. Metal-organic frameworks own sole inimitable features like catalytic functionalities, tuneability, and diversity recognized through chosen crystalline matrix on the edge of material and coordination interaction. Mediety array with coordination priority amid metal rigidity and the denticity of bound organic ligands to offer massive surface area under huge tiny holes besides robustness and permeability. Metal nodes in MOFs are facile to tailor consistent struts that impart diverse capacities in enduring networks and offer many unique features viz.; solitary topologies, huge surface area, and porosity as requisite in many fields including storage, conductive, bio-sensor, biomarking, emulsion formation and drug/gene/tissue delivery. The Schiff base functions are introduced into the structure of MOFs via post-synthetic modification. Post-synthetic variations embed advanced organo-metallics and likewise aid constructive metal clusters with bounded ligands within porous MOFs. Certain notable MOF motif yields via integrated varied guests such as metals, organic and inorganic ligands as well fused multi functionalities further provide assorted applicability. In this overview, MOF-based materials concern aspects like surface modification, structural alterations, and physicochemical characterization besides viable application domains in the advancement of applied disciplines in this epoch.</p> Graphical Abstract <p></p>