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<p>Graphene oxide (GO) and its composites have various biomedical applications and are known to exhibit biocidal activities. A nanocomposite based on GO, chitosan (CS), and polyvinyl alcohol (PVA) was prepared by a solution mixing method, and each component was casted in an aqueous solution. This designed nanocomposite displayed improved antibacterial properties, suggesting a new prototype against resistance to bacteria. To ensure sustained release and enhance long-term performance, the nanocomposite was incorporated into a hydrogel matrix. UV-visible spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), Scanning electron microscopy (SEM), and X-ray diffraction (XRD) were performed to study the dispersion of GO in the PVA-CS matrix. The peaks of UV-visible showed the degree of oxidation of GO and provide information about the bonds of different functional groups present in the composite. The variation of this GO-CS/PVA nanocomposites were prepared, and their antibacterial activity was studied using various concentrations of the prepared nanocomposite, which showed different inhibition zones. For this study, the Gram-negative bacilli <i>Escherichia coli</i>,<i> Klebsiella pneumoniae</i>,<i> and Pseudomonas aeruginosa</i> strains were used and an assessment was performed. GO and its nanocomposite exhibited antibacterial activity against bacteria, which can be observed in the inhibition zone.</p>

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Performance of Graphene Oxide Hydrogel Functionalized with Chitosan and Polyvinyl Alcohol for Enhanced Antibacterial Activities

  • 期刊论文

  • 发表日期：

    2025年2月21日

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  • Vijay Prakash Jain,
  • Gautam Jaiswar

摘要

Graphene oxide (GO) and its composites have various biomedical applications and are known to exhibit biocidal activities. A nanocomposite based on GO, chitosan (CS), and polyvinyl alcohol (PVA) was prepared by a solution mixing method, and each component was casted in an aqueous solution. This designed nanocomposite displayed improved antibacterial properties, suggesting a new prototype against resistance to bacteria. To ensure sustained release and enhance long-term performance, the nanocomposite was incorporated into a hydrogel matrix. UV-visible spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), Scanning electron microscopy (SEM), and X-ray diffraction (XRD) were performed to study the dispersion of GO in the PVA-CS matrix. The peaks of UV-visible showed the degree of oxidation of GO and provide information about the bonds of different functional groups present in the composite. The variation of this GO-CS/PVA nanocomposites were prepared, and their antibacterial activity was studied using various concentrations of the prepared nanocomposite, which showed different inhibition zones. For this study, the Gram-negative bacilli Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa strains were used and an assessment was performed. GO and its nanocomposite exhibited antibacterial activity against bacteria, which can be observed in the inhibition zone.