Synthesis of New 3-(Benzo[d]Oxazol-2-Yl)-3-(4-Fluorophenyl)Propanoic Acid Intermediate and its Derivatives as Antimicrobial Agent, Molecular Docking Studies

A series of new N-substituted 3-(benzo[d]oxazol-2-yl)-3-(4-fluorophenyl) propenamide derivatives has been synthesized using a series of reactions. Structure confirmation of the synthesized compounds was done by IR, ¹H NMR, ¹³C NMR, Chiral HPLC and ESI-MM MS analysis data. The in-vitro antimicrobial activity of the synthesized compounds was evaluated against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis. Antifungal activity has been performed on Candida albicans and Aspergillus niger. The results have revealed that the nature of substrate had profound effect on the biological activity. These results were compared with the control Ampicillin (antibacterial) and Clotrimazole (antifungal). Molecular docking and pharmacokinetic studies have been conducted on the selected compounds to further rationalize the results.