Over the years, the production of medicines has significantly increased, resulting in water pollution from pharmaceutical substances. This pollution has harmful effects on the ecological system and living beings. As a result, removing these contaminants from aqueous effluents has become a major concern. Anodic oxidation processes have shown potential for eliminating these contaminants due to the high oxidation capacity of hydroxyl radicals \(\left(\bullet \text{OH}\right)\) generated in aqueous environments. In this study, we aim to investigate the treatment of chlorpheniramine (CLP), an antihistamine drug, in an aqueous solution by anodic oxidation on boron-doped diamond. The performance of this process depends on various operating parameters such as the initial concentration of chlorpheniramine, the electric current density (J), the duration of the treatment, and the temperature of the reaction medium. We conducted a Doehlert experimental design to determine the optimal conditions for the treatment of chlorpheniramine by anodic oxidation (AO) on a boron-doped diamond (BDD) electrode. We found that the optimal conditions for treating chlorpheniramine were a concentration of 40.8 10–5 M, an electrical density of 87 mA cm−2 and a treatment time of 8 h at 37 ºC. Under these optimal conditions, we observed a 98% elimination of chemical oxygen demand (COD) and a 95% formation of nitrate ions. These results demonstrate the efficiency of the anodic oxidation on boron-doped diamond process in eliminating chlorpheniramine as a water waste in an aqueous medium.
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