Synthesis and Crystal Structure–Activity Studies and Possible Therapeutic Application of Diamine Conjugated Furil Schiff Base as Antibacterial Agent
摘要
A novel furil-based asymmetric Schiff base was prepared and characterized by analytical and spectroscopic methods. Schiff base could be produced by the amalgamation of furil with 1,2-diaminotoluene by employing conventional methods in variety of solvents. Synthesized compound was found to be asymmetric without possessing mirror plane and inversion center with all explained physical parameters possessed. Antibacterial activity was performed by in vitro test using an agar-well diffusion technique. This compound showed potent antibacterial activity compared to standard doxycycline drug. This compound could be a better drug candidate for antimicrobial infections though this area needs further persuasion and deliberation by the scientific community.