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<p>Developing advanced wound dressings with enhanced physical and biological properties is crucial for effective tissue regeneration. This study aims to fabricate and evaluate a novel nanocomposite scaffold comprising Hyaluronic Acid (HA) and Poly(vinyl alcohol) (PVA) matrices, reinforced with a ternary filler system of Iron(III) oxide (Fe<sub>2</sub>O<sub>3</sub>), Cadmium phosphate (Cd<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub>), and Carbon Nanotubes (CNTs). The composite films were synthesized utilizing a solution casting technique with varying ratios of the functional nanofillers. The structural, mechanical, and biological responses of the resulting scaffolds were systematically characterized to optimize their therapeutic potential. The incorporation of the ternary filler system significantly enhanced the physicochemical properties of the PVA/HA matrix. Surface morphological analysis confirmed a porous and highly rough topology. The composite films exhibited robust hydrophilicity, with water contact angles decreasing from 51.04º ± 3.56 to 46.21º ± 3.55, which facilitated superior wettability and drug-absorption capabilities. Thermal analysis indicated high structural stability, with the major polymer decomposition occurring near 425&#xa0;°C. Mechanically, the reinforced scaffolds demonstrated exceptional integrity; the elongation at break reached 238.3%, and tensile strength increased significantly from 0.8 ± 0.1&#xa0;MPa to 4.8 ± 0.8&#xa0;MPa. Biologically, the nanocomposites maintained excellent in vitro cytocompatibility, yielding cell viability exceeding 100% at low drug concentrations. Furthermore, the tailored release of Cd<sup>2+</sup> and Fe<sup>3+</sup> ions contributed to a potent antibacterial efficacy against <i>S. aureus</i>, <i>E. coli</i>, and <i>P. aeruginosa</i>. Consequently, the synergistic integration of the Cd<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub>/Fe<sub>2</sub>O<sub>3</sub>/CNT ternary system within the PVA/HA matrix successfully yielded a mechanically durable, highly absorbent, and biologically active scaffold. These findings demonstrate the high potential and practical application value of the fabricated nanocomposite films as advanced wound dressing materials.</p>

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Development of antibacterial activity of Cd3(PO4)2/Fe2O3/CNT reinforced Hyaluronic Acid/Poly (vinyl alcohol) scaffolds films for wound healing applications

  • 期刊论文

  • 发表日期：

    2026年6月23日

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  • Abdulrahman Saud Alhammad,
  • Mohamed Tharwat Elabbasy,
  • Anas Fathuldeen,
  • Madiha R. Mahmoud,
  • Mai Ali Abdelfattah Ahmed,
  • M. A. El-Morsy,
  • A. A. Menazea

摘要

Developing advanced wound dressings with enhanced physical and biological properties is crucial for effective tissue regeneration. This study aims to fabricate and evaluate a novel nanocomposite scaffold comprising Hyaluronic Acid (HA) and Poly(vinyl alcohol) (PVA) matrices, reinforced with a ternary filler system of Iron(III) oxide (Fe2O3), Cadmium phosphate (Cd3(PO4)2), and Carbon Nanotubes (CNTs). The composite films were synthesized utilizing a solution casting technique with varying ratios of the functional nanofillers. The structural, mechanical, and biological responses of the resulting scaffolds were systematically characterized to optimize their therapeutic potential. The incorporation of the ternary filler system significantly enhanced the physicochemical properties of the PVA/HA matrix. Surface morphological analysis confirmed a porous and highly rough topology. The composite films exhibited robust hydrophilicity, with water contact angles decreasing from 51.04º ± 3.56 to 46.21º ± 3.55, which facilitated superior wettability and drug-absorption capabilities. Thermal analysis indicated high structural stability, with the major polymer decomposition occurring near 425 °C. Mechanically, the reinforced scaffolds demonstrated exceptional integrity; the elongation at break reached 238.3%, and tensile strength increased significantly from 0.8 ± 0.1 MPa to 4.8 ± 0.8 MPa. Biologically, the nanocomposites maintained excellent in vitro cytocompatibility, yielding cell viability exceeding 100% at low drug concentrations. Furthermore, the tailored release of Cd2+ and Fe3+ ions contributed to a potent antibacterial efficacy against S. aureus, E. coli, and P. aeruginosa. Consequently, the synergistic integration of the Cd3(PO4)2/Fe2O3/CNT ternary system within the PVA/HA matrix successfully yielded a mechanically durable, highly absorbent, and biologically active scaffold. These findings demonstrate the high potential and practical application value of the fabricated nanocomposite films as advanced wound dressing materials.