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<p>Diabetic wounds present a major clinical challenge to health care professionals in recent years due to their complications, such as amputation, infection, chronic wound formation, and even death in many cases. Stimuli responsive hydrogels have emerged in recent years as promising candidates to solve this problem because of their novel properties, such as responsive behaviour towards specific stimuli, biocompatibility, moisture retention, promotion of angiogenesis, hemostatic behaviour, antibacterial effect and high drug loading capacity etc. These hydrogels can encapsulate therapeutic agents, including growth factors, organogelators, antibiotics and antioxidants to mitigate infection, reduce inflammation, scavenge reactive oxygen species (ROS), and facilitate healing. This work provides a comprehensive overview focusing on development in previous five years. It covers the materials, fabrication strategies, and therapeutic applications of stimuli responsive hydrogels in diabetic wound healing. This review also discusses the existing challenges and future directions for using these materials on a large scale.</p>

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Recent research progress in stimuli responsive hydrogels for the diabetic wound treatment: a review of current state and future perspectives

  • 期刊论文

  • 发表日期：

    2026年6月1日

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  • Saqlain Raza,
  • Li Wang,
  • Haojie Yu,
  • Muhammad Haroon,
  • Muhammad Owais Malik,
  • Abdul Basit,
  • Khan Manqoosh Awan,
  • Dileep Ahmad

摘要

Diabetic wounds present a major clinical challenge to health care professionals in recent years due to their complications, such as amputation, infection, chronic wound formation, and even death in many cases. Stimuli responsive hydrogels have emerged in recent years as promising candidates to solve this problem because of their novel properties, such as responsive behaviour towards specific stimuli, biocompatibility, moisture retention, promotion of angiogenesis, hemostatic behaviour, antibacterial effect and high drug loading capacity etc. These hydrogels can encapsulate therapeutic agents, including growth factors, organogelators, antibiotics and antioxidants to mitigate infection, reduce inflammation, scavenge reactive oxygen species (ROS), and facilitate healing. This work provides a comprehensive overview focusing on development in previous five years. It covers the materials, fabrication strategies, and therapeutic applications of stimuli responsive hydrogels in diabetic wound healing. This review also discusses the existing challenges and future directions for using these materials on a large scale.