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<p>In this research, pomegranate peels, generally regarded as waste, was employed to extract ellagic acid (EA) using promulgated methodologies under optimum experimental conditions. On chromatographical and spectroscopical analysis, the presence of 93.3% of EA was confirmed in 2.2 gram of extracted aliquot part. Afterwards, zirconium–ellagate framework i.e., SU-102 MOF E and SU-102 MOF C were synthesized using the same organic linker but from different sources (EA extracted from fruit waste and commercially available EA respectively) and zirconyl chloride octahydrate in 1:2 ratio of deionized water and N, N-dimethylformamide (DMF) and 15 mL of acetic acid under reflux conditions at 80&#xa0;°C for 48&#xa0;h. The synthesis of laboratory synthesized biomolecule-based metal-organic frameworks (Bio-MOFs) were confirmed through microscopical and spectroscopy analysis tools before exploring the main objective of the research. To facilitate the research proceeding on ideal drug delivery vehicles, cytotoxicity analysis on L929 cell line (murine fibroblast) was conducted by MTT assay and also the antioxidant properties of SU-102 MOF E were explored by DPP assay. The results showed that the % cell viability exceeded 70% and the radical scavenging activity was found to 89.8%. Importantly, theoretical calculations using Gaussian09 (Revision D.01) suite of quantum chemical programs was performed to find possible mode of interactions between SU-102 MOF E and ibuprofen (IBU) followed by spectroscopic and microscopic analysis. Finally, we found 97% of IBU released within 165&#xa0;min from IBU@ SU-102 MOF E under <i>in-vitro conditions.</i> It reveals a great possibility for biocompatibility, safety, and selectivity drug vehicle in future.</p>

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Synthesis and analysis of zirconium – ellagate framework from pomegranate husk waste-based ellagic acid for ibuprofen delivery – a model study

  • 期刊论文

  • 发表日期：

    2026年3月17日

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  • Manu Sharma,
  • Muskan,
  • Avtar Changotra,
  • Pawan Kumar

摘要

In this research, pomegranate peels, generally regarded as waste, was employed to extract ellagic acid (EA) using promulgated methodologies under optimum experimental conditions. On chromatographical and spectroscopical analysis, the presence of 93.3% of EA was confirmed in 2.2 gram of extracted aliquot part. Afterwards, zirconium–ellagate framework i.e., SU-102 MOF E and SU-102 MOF C were synthesized using the same organic linker but from different sources (EA extracted from fruit waste and commercially available EA respectively) and zirconyl chloride octahydrate in 1:2 ratio of deionized water and N, N-dimethylformamide (DMF) and 15 mL of acetic acid under reflux conditions at 80 °C for 48 h. The synthesis of laboratory synthesized biomolecule-based metal-organic frameworks (Bio-MOFs) were confirmed through microscopical and spectroscopy analysis tools before exploring the main objective of the research. To facilitate the research proceeding on ideal drug delivery vehicles, cytotoxicity analysis on L929 cell line (murine fibroblast) was conducted by MTT assay and also the antioxidant properties of SU-102 MOF E were explored by DPP assay. The results showed that the % cell viability exceeded 70% and the radical scavenging activity was found to 89.8%. Importantly, theoretical calculations using Gaussian09 (Revision D.01) suite of quantum chemical programs was performed to find possible mode of interactions between SU-102 MOF E and ibuprofen (IBU) followed by spectroscopic and microscopic analysis. Finally, we found 97% of IBU released within 165 min from IBU@ SU-102 MOF E under in-vitro conditions. It reveals a great possibility for biocompatibility, safety, and selectivity drug vehicle in future.