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<p>Sericin, a natural silk protein, demonstrates exceptional biocompatibility and comprises bioactive compounds that facilitate wound healing. This study effectively produced sericin-incorporated hydrogels to examine their fundamental features, including the sericin release profile, hence validating their potential for tissue regeneration and biomedical applications. The physical characteristics and the impact of electrical potentials on the release of sericin from gelatin hydrogels under a system with and without positive and negative external voltages were investigated through the effective fabrication of gelatin hydrogels containing sericin. The surface appearance of both non- and sericin-containing hydrogels was smooth, glossy, soft, and without porosity. However, using a mass comparison technique, it was discovered that the average porosity percentages of the hydrogels were not significantly different between those with and without sericin. Fabricated hydrogels exhibited hydrophobic properties during the first 90&#xa0;s of the examination. After that, the hydrogels became more hydrophilic. The hydrogels that contained sericin exhibited superior water absorption compared to those that did not. One important finding was that the fabricated hydrogels with sericin were approximately seven times more stretchable than the hydrogels without sericin, indicating greater flexibility and durability. Furthermore, it was revealed that the release of sericin increased with the length of stimulation. The optimal external voltage to induce the release of sericin from the hydrogels was a negative external voltage of 0.5&#xa0;V, which produced an adequate amount of sericin to inhibit bacterial growth, hence influencing inflammation and wound healing.</p>

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Physical properties and sericin releasing behavior with/without electrical stimulation of sericin/gelatin hydrogels as wound dressing and healing materials

  • 期刊论文

  • 发表日期：

    2025年10月17日

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  • Puripat Kantha,
  • Pannawit Wutthikunthanaroj,
  • Jitranuch Wanlang,
  • Nanjaporn Roungpaisan,
  • Ruamporn Potong,
  • Siriwan Teepoo,
  • Naris Barnthip

摘要

Sericin, a natural silk protein, demonstrates exceptional biocompatibility and comprises bioactive compounds that facilitate wound healing. This study effectively produced sericin-incorporated hydrogels to examine their fundamental features, including the sericin release profile, hence validating their potential for tissue regeneration and biomedical applications. The physical characteristics and the impact of electrical potentials on the release of sericin from gelatin hydrogels under a system with and without positive and negative external voltages were investigated through the effective fabrication of gelatin hydrogels containing sericin. The surface appearance of both non- and sericin-containing hydrogels was smooth, glossy, soft, and without porosity. However, using a mass comparison technique, it was discovered that the average porosity percentages of the hydrogels were not significantly different between those with and without sericin. Fabricated hydrogels exhibited hydrophobic properties during the first 90 s of the examination. After that, the hydrogels became more hydrophilic. The hydrogels that contained sericin exhibited superior water absorption compared to those that did not. One important finding was that the fabricated hydrogels with sericin were approximately seven times more stretchable than the hydrogels without sericin, indicating greater flexibility and durability. Furthermore, it was revealed that the release of sericin increased with the length of stimulation. The optimal external voltage to induce the release of sericin from the hydrogels was a negative external voltage of 0.5 V, which produced an adequate amount of sericin to inhibit bacterial growth, hence influencing inflammation and wound healing.