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<p>The need for biomedical composite materials with specific toughness, non-toxicity, and biocompatibility with bending and twisting characteristics has increased recently. In our study, a piezoelectric polyvinylidene fluoride (PVDF) blended with thermoplastic polyurethane (TPU) nanofibers were manufactured using solution blow spinning method. The fabricated nanofibers were characterized morphologically by SEM, mechanically by texture analyzer CTX, and piezo-electrically by high impedance oscilloscope. The antibacterial influence of localized piezoelectric fields generated from the nanofibers was studied against <i>K. pneumoniae in this research</i>. Remarkable mechanical improvement of fabricated PVDF: TPU 10% membranes to get maximum elongation of 9.2% at tensile strengths of 46.5&#xa0;MPa. The PVDF pure material achieved a peak output voltage of 0.76&#xa0;V, while the PVDF: TPU 10% nanofibrous composite reaches 0.7&#xa0;V. Under cyclic mechanical loading (2.5&#xa0;N), PVDF: TPU 10% exhibited nonlinear voltage behavior with a peak output of 3.3&#xa0;V at 1&#xa0;Hz, whereas pure PVDF maintained a constant output of 0.5&#xa0;V across frequencies. On the other hand, the maximum antibacterial effect was obtained by applying weak localized electrical fields at 1.5&#xa0;Hz generated from pure PVDF nanofibrous. It showed maximum growth inhibition by 50% reduction, highest LDH and protein leakage levels by 250% and 143% respectively, and remarkable dielectric dispersions at the frequency range &lt; 2&#xa0;MHz and ≈ 5&#xa0;MHz. In conclusion, the fabricated solution blown nanofibrous PVDF-TPU showed mechanical improvement, exhibiting a maximum elongation of 9.2% at 46.5&#xa0;MPa and 6.9% at 14.9&#xa0;MPa for nanofibrous PVDF alone. The novelty of using nanofibrous membranes as an antibacterial agent with a higher antibacterial effect that resulted from PVDF pure nanofibrous membranes.</p> Graphical abstract <p></p>

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Antimicrobial impact of locally generated piezoelectric fields from solution-blown PVDF/PVDF-TPU nanofiber mats

  • 期刊论文

  • 发表日期：

    2025年9月23日

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  • Nader Shehata,
  • Alaa M. Khalil,
  • Ahmed. M. El-Khatib,
  • Nada Omran,
  • Mohammed Gamal,
  • Germein Magdy,
  • Ahmed H. Hassanin,
  • Ishac Kandas,
  • Islam Shyha,
  • Marwa Saad,
  • Mai. I. El-kaliuoby

摘要

The need for biomedical composite materials with specific toughness, non-toxicity, and biocompatibility with bending and twisting characteristics has increased recently. In our study, a piezoelectric polyvinylidene fluoride (PVDF) blended with thermoplastic polyurethane (TPU) nanofibers were manufactured using solution blow spinning method. The fabricated nanofibers were characterized morphologically by SEM, mechanically by texture analyzer CTX, and piezo-electrically by high impedance oscilloscope. The antibacterial influence of localized piezoelectric fields generated from the nanofibers was studied against K. pneumoniae in this research. Remarkable mechanical improvement of fabricated PVDF: TPU 10% membranes to get maximum elongation of 9.2% at tensile strengths of 46.5 MPa. The PVDF pure material achieved a peak output voltage of 0.76 V, while the PVDF: TPU 10% nanofibrous composite reaches 0.7 V. Under cyclic mechanical loading (2.5 N), PVDF: TPU 10% exhibited nonlinear voltage behavior with a peak output of 3.3 V at 1 Hz, whereas pure PVDF maintained a constant output of 0.5 V across frequencies. On the other hand, the maximum antibacterial effect was obtained by applying weak localized electrical fields at 1.5 Hz generated from pure PVDF nanofibrous. It showed maximum growth inhibition by 50% reduction, highest LDH and protein leakage levels by 250% and 143% respectively, and remarkable dielectric dispersions at the frequency range < 2 MHz and ≈ 5 MHz. In conclusion, the fabricated solution blown nanofibrous PVDF-TPU showed mechanical improvement, exhibiting a maximum elongation of 9.2% at 46.5 MPa and 6.9% at 14.9 MPa for nanofibrous PVDF alone. The novelty of using nanofibrous membranes as an antibacterial agent with a higher antibacterial effect that resulted from PVDF pure nanofibrous membranes.

Graphical abstract