Scholarlink

<p>There are many green electrospun nanofibers (ESNFs) loaded with seed oils. Among them, <i>Nigella sativa</i> oil (NSO) possesses various beneficial properties, such as pain relief, anti-inflammatory, antioxidant, anticancer, antimicrobial, antihypertensive, immune-stimulating, and wound healing effects. In this study, the characterization and in vitro cell viability testing of NSO (also known as black cumin oil) loaded polycaprolactone/κ-carrageenan (PCL-Car) nanofibrous mats were investigated for skin tissue engineering. SEM images and contact angle measurements of PCL-Car/NSO nanofibers were carried out. in vitro cell culture studies were conducted on human keratinocyte cells (HaCaT cell line). 10&#xa0;mg mL⁻¹ of NSO loaded PCL-Car/NSO nanofibers increased the viability of HaCaT cells within 48&#xa0;h. In addition, PCL-Car/NSO nanofibers showed advanced wound healing activities (48%). Consequently, PCL-Car/NSO nanofibers have a favorable usage potential in skin tissue engineering applications. </p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Black cumin oil-loaded polycaprolactone/κ-carrageenan electrospun nanofibers for wound healing applications

  • 期刊论文

  • 发表日期：

    2025年9月9日

查看全文
  • Ozan Yesiltepe,
  • Ozge Kozgus Guldu,
  • Gozde Atik,
  • Emin Ilker Medine,
  • Dilek Odaci

摘要

There are many green electrospun nanofibers (ESNFs) loaded with seed oils. Among them, Nigella sativa oil (NSO) possesses various beneficial properties, such as pain relief, anti-inflammatory, antioxidant, anticancer, antimicrobial, antihypertensive, immune-stimulating, and wound healing effects. In this study, the characterization and in vitro cell viability testing of NSO (also known as black cumin oil) loaded polycaprolactone/κ-carrageenan (PCL-Car) nanofibrous mats were investigated for skin tissue engineering. SEM images and contact angle measurements of PCL-Car/NSO nanofibers were carried out. in vitro cell culture studies were conducted on human keratinocyte cells (HaCaT cell line). 10 mg mL⁻¹ of NSO loaded PCL-Car/NSO nanofibers increased the viability of HaCaT cells within 48 h. In addition, PCL-Car/NSO nanofibers showed advanced wound healing activities (48%). Consequently, PCL-Car/NSO nanofibers have a favorable usage potential in skin tissue engineering applications.

Graphical Abstract