<p>When a bone-like trauma is beyond critical size defect, bone implants become an absolute necessity and a scaffold that can induce bone regeneration and proliferation without inducing any adverse effect on the surrounding tissues is the best way to overcome this difficulty. Since the development of bioresorbable scaffolds provides a preferred alternative to autografts, allografts, and bioinert implants due to their promising bioactivity, biocompatibility, and biodegradation, we have undertaken the fabrication of perforated PVA-PVP-Chitosan scaffold via electrospinning by incorporating silica particles into it and the impact of variation of silica concentration on the scaffold is studied. The interconnected structures observed by SEM analysis could enhance many of the properties of the scaffold such as hydrophilicity, bioactivity as well as tensile strength. The biodegradability of the scaffolds was assessed for 28 days and they provided a controlled biodegradation rate due to the perforated structure. The swelling properties and wettability analysis of the scaffolds proved them to be hydrophilic. The higher rate of interconnectivity gave an increased tensile strength to the scaffold, and the addition of chitosan increased the antibacterial properties of the scaffolds which was proven by the disc diffusion method as well as CFU. A well-developed apatite was observed by the 7th day of SBF immersion with a Ca/P ratio of 1.6. Cell viability of the samples were studied and the assay proved the samples to be biocompatible.</p>