<p>Materials based on the rare earth metal manganites are promising for use as cathodes of solid oxide fuel cells (SOFC), catalysts for gas oxidation and electronic devices. The paper presents a comparative analysis of the effect of substitution on A and B -sublattices on the microstructure, electrical conductivity, structural and magnetic properties of the Eu_1−xSr_xMn_1−yFe_yO₃ oxides (x = 0.0;0.15;0.25) (y = 0.0;0.1). The samples synthesized by the ceramic method have a perovskite structure. The Jahn-Teller (JT) phase transition caused by an increase in temperature is observed for all investigated manganites. The temperature of this transition decreases both with increasing the level of substitution of europium as well as with simultaneous substitution along Eu and Mn -sublattices. Eu/Sr substitution changes the microstructure of the initial manganite, leading to a decrease in the grain size and the appearance of pores. Additional Mn/Fe substitution provokes the grain agglomeration. All the investigated manganites demonstrate the antiferromagnetic - ferromagnetic (AFM - FM) transition and the semiconductor nature of the conductivity. The magnetic and electrical characteristics of europium manganite enhance with increasing the Eu/Sr substitution. However, the substitution of Mn with Fe reduces this effect. Relationships between the composition and structure stability, changes in microstructure, magnetic and electrical properties are discussed. Our study shows the importance of controlled substitution at europium manganites, aimed to improving of their physico-chemical properties. It contribute the expansion of the range of potential materials for SOFC cathodes.</p>