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<p>Pathogenic microorganism drug resistance has become a global health problem that is driving the development of novel antimicrobial materials. Metal–organic nanocomposites that operate through synergy offer a promising solution in this context. In this study, we synthesized substituted dihydropyrimidinone derivatives from substituted aromatic aldehydes, urea, and ethyl acetoacetate using a one-pot multicomponent Biginelli reaction. The antimicrobial potential of metal nanoparticles, particularly silver nanoparticles, is well-documented, and the antibacterial properties of dihydropyrimidinone derivatives are also well established. Hence, we combined the prepared Biginelli compounds with silver nanoparticles to form metal–organic nanocomposites that were subsequently screened for their antibacterial activities. The <b>ABS-H2</b> nanocomposite exhibited concentration- and time-dependent behavior against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. Finally, cotton fabric was endowed with antibacterial properties by applying this nanocomposite.</p>

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Development of an antibacterial Biginelli-based metal–organic nanocomposite-coated cotton fabric

  • 期刊论文

  • 发表日期：

    2025年5月20日

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  • Bulle Shah,
  • Narinder Singh,
  • Doo Ok Jang

摘要

Pathogenic microorganism drug resistance has become a global health problem that is driving the development of novel antimicrobial materials. Metal–organic nanocomposites that operate through synergy offer a promising solution in this context. In this study, we synthesized substituted dihydropyrimidinone derivatives from substituted aromatic aldehydes, urea, and ethyl acetoacetate using a one-pot multicomponent Biginelli reaction. The antimicrobial potential of metal nanoparticles, particularly silver nanoparticles, is well-documented, and the antibacterial properties of dihydropyrimidinone derivatives are also well established. Hence, we combined the prepared Biginelli compounds with silver nanoparticles to form metal–organic nanocomposites that were subsequently screened for their antibacterial activities. The ABS-H2 nanocomposite exhibited concentration- and time-dependent behavior against Escherichia coli and Staphylococcus aureus. Finally, cotton fabric was endowed with antibacterial properties by applying this nanocomposite.