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<p>This study investigated MnFe<sub>2</sub>O<sub>4</sub>/NiO biphasic nanocomposites for treating neoplasm through magnetic hyperthermia therapy. For this purpose, a solid-state synthesis was utilized to produce the nanocomposites of MnFe<sub>2</sub>O<sub>4</sub> + xNiO with x = 10–40 wt%; while their precursors: MnFe<sub>2</sub>O<sub>4</sub> and NiO nanopowders were individually synthesized by co-precipitation method. The MnFe<sub>2</sub>O<sub>4</sub> nanoparticles exhibited a spherical shape with an average particle size of 10&#xa0;nm, while the NiO showed rod-shaped morphology with a diameter of 6&#xa0;nm. All the biphasic nanocomposites revealed a superparamagnetic nature with very low coercivity and remanence values. The magnetic parameters, such as T<sub>2</sub>-relaxation time and effective magnetic anisotropy, were calculated from the electron spin resonance spectra. Magnetic hyperthermia and cytotoxicity experiments were conducted for treating the A-549 lung neoplasm cells, and these studies apparently demonstrated the enhanced performance for the biphasic nanocomposites containing 10 wt% of NiO in terms of effective specific absorption rate (32.31 × 10<sup>−9</sup> W/gOe<sup>2</sup>Hz) and selectivity index (4.5 with IC<sub>50</sub> value of 20 ± 0.89&#xa0;µg/ml). The MnFe<sub>2</sub>O<sub>4</sub> + 10wt.% NiO nanocomposites showed improved anti-proliferation activity when compared to the other variants of nanocomposites; by this means, they provide a scope for the treatment of various cancer cells.</p>

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Enhancing the magnetic hyperthermia characteristics and cytotoxicity analysis of biphasic MnFe2O4/NiO nanocomposites

  • 期刊论文

  • 发表日期：

    2025年2月4日

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  • G. Nandhini,
  • M. K. Shobana,
  • P. Saravanan,
  • R. Justin Joseyphus,
  • J. Sriram,
  • Tiasha Dasgupta,
  • M. Venkatraman

摘要

This study investigated MnFe2O4/NiO biphasic nanocomposites for treating neoplasm through magnetic hyperthermia therapy. For this purpose, a solid-state synthesis was utilized to produce the nanocomposites of MnFe2O4 + xNiO with x = 10–40 wt%; while their precursors: MnFe2O4 and NiO nanopowders were individually synthesized by co-precipitation method. The MnFe2O4 nanoparticles exhibited a spherical shape with an average particle size of 10 nm, while the NiO showed rod-shaped morphology with a diameter of 6 nm. All the biphasic nanocomposites revealed a superparamagnetic nature with very low coercivity and remanence values. The magnetic parameters, such as T2-relaxation time and effective magnetic anisotropy, were calculated from the electron spin resonance spectra. Magnetic hyperthermia and cytotoxicity experiments were conducted for treating the A-549 lung neoplasm cells, and these studies apparently demonstrated the enhanced performance for the biphasic nanocomposites containing 10 wt% of NiO in terms of effective specific absorption rate (32.31 × 10−9 W/gOe2Hz) and selectivity index (4.5 with IC50 value of 20 ± 0.89 µg/ml). The MnFe2O4 + 10wt.% NiO nanocomposites showed improved anti-proliferation activity when compared to the other variants of nanocomposites; by this means, they provide a scope for the treatment of various cancer cells.