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<p>With the rising global prevalence of breast cancer, the development of innovative, low-toxicity, and highly effective therapeutic approaches has become a central focus of research. Despite the powerful anticancer properties, curcumin (CUR) faces challenges in clinical application due to poor water solubility and low systemic bioavailability. To address this issue, this study presents the development of a Zeolitic Imidazolate Framework (ZIF-8)/ Zirconium dioxide (ZrO₂) nanocomposite loaded with CUR and encapsulated in alginate (Alg) polymer matrix to enhance its solubility and therapeutic effectiveness. Characterization techniques such as X-ray powder diffraction (XRD) and thermogravimetric analysis (TGA) confirmed that incorporating various amounts of ZrO₂ nanoparticles significantly enhanced the structural stability and thermal resistance of the nanocomposites. The increase in hydrodynamic size supported the successful drug loading and polymer encapsulation. The morphological analysis displayed effective integration of nanocomposite and its encapsulated in Alg matrix. The Alg-CUR-ZIF-8/ZrO₂-C nanocomposite showcased a controlled drug release profile due to the polymer coating, with a release efficiency of 68.5% after 48&#xa0;h. The release kinetics of the formulations were evaluated, with the Alg/CUR-ZIF-8/ZrO₂-C nanocomposite showing the best fit to the zero-order model, achieving a high correlation coefficient (R²) of 0.9822. In-vitro studies on MDA-MB-231 breast cancer cells revealed that the nanocomposite caused notable cytotoxic effects in a time- and dose-dependent manner, with cell viability decreasing to 18.04% after 48&#xa0;h of treatment. These results indicate that the Alg-CUR-ZIF-8/ZrO₂ - C nanocomposite is a promising and effective therapeutic strategy for breast cancer, overcoming key limitations of traditional therapies while boosting the efficacy of CUR.</p> Graphical Abstract <p></p>

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Insights into the potential of polymer-encapsulated ZIF/ZrO₂ nanocomposite with curcumin for Anticancer Therapy

  • 期刊论文

  • 发表日期：

    2025年1月28日

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  • Swetha Shanmugam,
  • Harishankar Ranjith,
  • Amutha Santhanam

摘要

With the rising global prevalence of breast cancer, the development of innovative, low-toxicity, and highly effective therapeutic approaches has become a central focus of research. Despite the powerful anticancer properties, curcumin (CUR) faces challenges in clinical application due to poor water solubility and low systemic bioavailability. To address this issue, this study presents the development of a Zeolitic Imidazolate Framework (ZIF-8)/ Zirconium dioxide (ZrO₂) nanocomposite loaded with CUR and encapsulated in alginate (Alg) polymer matrix to enhance its solubility and therapeutic effectiveness. Characterization techniques such as X-ray powder diffraction (XRD) and thermogravimetric analysis (TGA) confirmed that incorporating various amounts of ZrO₂ nanoparticles significantly enhanced the structural stability and thermal resistance of the nanocomposites. The increase in hydrodynamic size supported the successful drug loading and polymer encapsulation. The morphological analysis displayed effective integration of nanocomposite and its encapsulated in Alg matrix. The Alg-CUR-ZIF-8/ZrO₂-C nanocomposite showcased a controlled drug release profile due to the polymer coating, with a release efficiency of 68.5% after 48 h. The release kinetics of the formulations were evaluated, with the Alg/CUR-ZIF-8/ZrO₂-C nanocomposite showing the best fit to the zero-order model, achieving a high correlation coefficient (R²) of 0.9822. In-vitro studies on MDA-MB-231 breast cancer cells revealed that the nanocomposite caused notable cytotoxic effects in a time- and dose-dependent manner, with cell viability decreasing to 18.04% after 48 h of treatment. These results indicate that the Alg-CUR-ZIF-8/ZrO₂ - C nanocomposite is a promising and effective therapeutic strategy for breast cancer, overcoming key limitations of traditional therapies while boosting the efficacy of CUR.

Graphical Abstract