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<p>This review article presents a comprehensive overview of emerging technologies in bone tissue engineering (BTE). This rapidly advancing field addresses the challenges of bone defects and injuries beyond traditional treatments like autografts and allografts. The study highlights the integration of 3D bioprinting, stem cell therapy, gene therapy, biomaterials, nanotechnology, and computational modeling as transformative approaches in BTE. Developing biomimetic scaffolds, advanced bio-inks, and composite nanomaterials has enhanced scaffold design, improving mechanical properties and biocompatibility. Innovations in gene therapy and bioactive molecule delivery are showcased for their ability to modulate cellular behavior and enhance osteogenesis. Stem cell-based therapies leverage the regenerative potential of mesenchymal stem cells, facilitating tissue integration and functional restoration. Computational tools, including finite element analysis (FEA) and agent-based modelling, aid in the optimization of scaffold design, predicting mechanical responses and biological behaviors. Despite notable progress, significant challenges, such as achieving reliable vascularization, scalable manufacturing of engineered constructs, and effective clinical translation, remain substantial barriers to widespread adoption. Future research efforts focused on refining these technologies are vital for translating innovative strategies into clinical practice, paving the way for personalized regenerative solutions in bone repair.</p>

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Emerging Technologies in Bone Tissue Engineering: A Review

  • 期刊论文

  • 发表日期：

    2025年9月4日

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  • Sonali Rastogi,
  • Ritu Verma,
  • Sampath A. Gouru,
  • Krishnaraju Venkatesan,
  • P. Muthu Pandian,
  • Mohd Ianveer Khan,
  • Trinayan Deka,
  • Pawan Kumar

摘要

This review article presents a comprehensive overview of emerging technologies in bone tissue engineering (BTE). This rapidly advancing field addresses the challenges of bone defects and injuries beyond traditional treatments like autografts and allografts. The study highlights the integration of 3D bioprinting, stem cell therapy, gene therapy, biomaterials, nanotechnology, and computational modeling as transformative approaches in BTE. Developing biomimetic scaffolds, advanced bio-inks, and composite nanomaterials has enhanced scaffold design, improving mechanical properties and biocompatibility. Innovations in gene therapy and bioactive molecule delivery are showcased for their ability to modulate cellular behavior and enhance osteogenesis. Stem cell-based therapies leverage the regenerative potential of mesenchymal stem cells, facilitating tissue integration and functional restoration. Computational tools, including finite element analysis (FEA) and agent-based modelling, aid in the optimization of scaffold design, predicting mechanical responses and biological behaviors. Despite notable progress, significant challenges, such as achieving reliable vascularization, scalable manufacturing of engineered constructs, and effective clinical translation, remain substantial barriers to widespread adoption. Future research efforts focused on refining these technologies are vital for translating innovative strategies into clinical practice, paving the way for personalized regenerative solutions in bone repair.