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<p><i>Panax ginseng</i> is a perennial medicinal plant. Ginseng has a long growth cycle and is susceptible to pathogenic bacteria and infections by a variety of diseases during the growth process. Root rot is a common disease that primarily affects ginseng roots. <i>Fusarium oxysporum</i> is a highly pathogenic fungus that causes ginseng root rot. In this study, a metabolomics technique in combination with multivariate statistical analysis was used to analyze metabolite changes in ginseng in response to <i>Fusarium oxysporum</i> infection. The findings indicated that the content of metabolites in ginseng changed with an increase in <i>Fusarium oxysporum</i> infection time. By analyzing and comparing the metabolites, 26 different metabolites were identified, including saponins, sugars, and organic acids. The saponin content was remarkably upregulated in the early stage and downregulated in the later stage. It is speculated that the synthesis pathway of saponins might be hindered by pathogen infection, and saponins might be pathogenic substances. The contents of some organic acids and sugars are upregulated, and they may be disease-resistant. Metabolic pathway analysis was performed for differential metabolites. Seven metabolic pathways have been annotated. In this study, the metabolites of ginseng infected by <i>Fusarium oxysporum</i> were preliminarily elucidated using metabolomics technology, which revealed the foundation of substance changes in ginseng infected by <i>Fusarium oxysporum</i> and also provided a reference for subsequent research on the defense mechanism of root rot disease in ginseng.</p>

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A comparative metabolomics study of Panax ginseng infected by Fusarium oxysporum

  • 期刊论文

  • 发表日期：

    2025年5月8日

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  • Wenhui Lian,
  • Chunhui Yu,
  • Guijia Zhao,
  • Xu Yang,
  • Lin Feng,
  • Jifeng Wang,
  • Wei Liu,
  • Yu Zhao

摘要

Panax ginseng is a perennial medicinal plant. Ginseng has a long growth cycle and is susceptible to pathogenic bacteria and infections by a variety of diseases during the growth process. Root rot is a common disease that primarily affects ginseng roots. Fusarium oxysporum is a highly pathogenic fungus that causes ginseng root rot. In this study, a metabolomics technique in combination with multivariate statistical analysis was used to analyze metabolite changes in ginseng in response to Fusarium oxysporum infection. The findings indicated that the content of metabolites in ginseng changed with an increase in Fusarium oxysporum infection time. By analyzing and comparing the metabolites, 26 different metabolites were identified, including saponins, sugars, and organic acids. The saponin content was remarkably upregulated in the early stage and downregulated in the later stage. It is speculated that the synthesis pathway of saponins might be hindered by pathogen infection, and saponins might be pathogenic substances. The contents of some organic acids and sugars are upregulated, and they may be disease-resistant. Metabolic pathway analysis was performed for differential metabolites. Seven metabolic pathways have been annotated. In this study, the metabolites of ginseng infected by Fusarium oxysporum were preliminarily elucidated using metabolomics technology, which revealed the foundation of substance changes in ginseng infected by Fusarium oxysporum and also provided a reference for subsequent research on the defense mechanism of root rot disease in ginseng.