Scholarlink

<p>Diabetic wounds exhibit persistent inflammation and endoplasmic reticulum (ER) stress (ERS) in high-glucose environments, leading to cellular dysfunction and limited tissue regeneration, which poses a significant challenge for clinical treatment. In this study, we developed a reactive oxygen species (ROS)-responsive hydrogel (HPA@A&amp;T) that promotes the healing of diabetic wounds by restoring cellular homeostasis through the mitigation of the ERS. The hydrogel consists of polyvinyl alcohol and hyaluronic acid-grafted 3-amino phenylboronic acid, which rapidly forms a gel via a phenylboronate bond that can be severed at high-ROS levels to achieve targeted degradation and drug release. The hydrogel encapsulates both the astaxanthin-zinc ion complex and tauroursodeoxycholic acid, which act synergistically to downregulate the expression of the unfolded protein response core proteins protein kinase RNA-like ER kinase (PERK), eukaryotic translation initiation factor 2α (eIF2α), activating transcription factor-4 (ATF4), and C/EBP homologous protein (CHOP), thereby contributing to the restoration of ER homeostasis and cellular function. HPA@A&amp;T hydrogels have demonstrated biocompatibility in both cellular and animal studies, enhancing cellular activity and promoting wound healing. In conclusion, HPA@A&amp;T hydrogels can be triggered by ROS to release drugs, effectively regulate cellular ERS levels, and maintain cellular homeostasis through the PERK-eIF2α-ATF4-CHOP pathway, providing a novel smart response strategy for the treatment of diabetic wounds.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Reactive oxygen species-responsive hydrogel accelerates diabetic wound repair by modulating endoplasmic reticulum stress

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月16日

查看全文
  • Songjie Li,
  • Han Chen,
  • Xin Dan,
  • Yikun Ju,
  • Pu Yang,
  • Yang Li,
  • Lanjie Lei,
  • Xing Fan

摘要

Diabetic wounds exhibit persistent inflammation and endoplasmic reticulum (ER) stress (ERS) in high-glucose environments, leading to cellular dysfunction and limited tissue regeneration, which poses a significant challenge for clinical treatment. In this study, we developed a reactive oxygen species (ROS)-responsive hydrogel (HPA@A&T) that promotes the healing of diabetic wounds by restoring cellular homeostasis through the mitigation of the ERS. The hydrogel consists of polyvinyl alcohol and hyaluronic acid-grafted 3-amino phenylboronic acid, which rapidly forms a gel via a phenylboronate bond that can be severed at high-ROS levels to achieve targeted degradation and drug release. The hydrogel encapsulates both the astaxanthin-zinc ion complex and tauroursodeoxycholic acid, which act synergistically to downregulate the expression of the unfolded protein response core proteins protein kinase RNA-like ER kinase (PERK), eukaryotic translation initiation factor 2α (eIF2α), activating transcription factor-4 (ATF4), and C/EBP homologous protein (CHOP), thereby contributing to the restoration of ER homeostasis and cellular function. HPA@A&T hydrogels have demonstrated biocompatibility in both cellular and animal studies, enhancing cellular activity and promoting wound healing. In conclusion, HPA@A&T hydrogels can be triggered by ROS to release drugs, effectively regulate cellular ERS levels, and maintain cellular homeostasis through the PERK-eIF2α-ATF4-CHOP pathway, providing a novel smart response strategy for the treatment of diabetic wounds.