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<p>Severe osteoarthritis often necessitates artificial joint replacement, yet conventional designs remain challenged by mismatched mechanics with native bone, metal ion release, and wear-induced inflammation. Here, we introduce a cartilage-inspired biomimetic artificial joint (BAJ) engineered with a polyether-ether-ketone (PEEK) substrate and a hydrogel (κ-carrageenan/polyacrylamide) cartilage layer. Distinct from existing implants, the BAJ integrates a gradient structure in which deeper layers provide robust load-bearing capacity, while the lubricating surface layer ensures ultra-low friction. This architecture enables a sliding friction coefficient as low as 0.004, withstanding more than 1.27&#xa0;million friction cycles and an exceptionally low mass wear rate of 7.1 × 10<sup>− 7</sup> mg/cycle. Cellular assays and in vivo subcutaneous implantation confirmed outstanding biocompatibility, while long-term wear tests in Beagle temporomandibular joints demonstrated remarkable durability over nine months without systemic toxicity. By harnessing a biomimetic gradient design, this study offers a transformative strategy for next-generation artificial joints, capable of mitigating severe inflammation and extending implant longevity.</p>

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Bio-inspired Multi-layer structure artificial joint for In vivo wear resistant

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月9日

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  • Shan Lu,
  • Liguo Qin,
  • Zihui Zhao,
  • Zeguo Feng,
  • Zeyu Ma,
  • Yuhao Wu,
  • Zheng Wang,
  • Xiaodong Huang,
  • Jianbo Liu,
  • Jun Qiu,
  • Taiqiang Dai,
  • Yiwen Liu,
  • Yuanli Chen,
  • Lei Tian

摘要

Severe osteoarthritis often necessitates artificial joint replacement, yet conventional designs remain challenged by mismatched mechanics with native bone, metal ion release, and wear-induced inflammation. Here, we introduce a cartilage-inspired biomimetic artificial joint (BAJ) engineered with a polyether-ether-ketone (PEEK) substrate and a hydrogel (κ-carrageenan/polyacrylamide) cartilage layer. Distinct from existing implants, the BAJ integrates a gradient structure in which deeper layers provide robust load-bearing capacity, while the lubricating surface layer ensures ultra-low friction. This architecture enables a sliding friction coefficient as low as 0.004, withstanding more than 1.27 million friction cycles and an exceptionally low mass wear rate of 7.1 × 10− 7 mg/cycle. Cellular assays and in vivo subcutaneous implantation confirmed outstanding biocompatibility, while long-term wear tests in Beagle temporomandibular joints demonstrated remarkable durability over nine months without systemic toxicity. By harnessing a biomimetic gradient design, this study offers a transformative strategy for next-generation artificial joints, capable of mitigating severe inflammation and extending implant longevity.