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<p>Tumor thermotolerance, limited heat penetration in deep tissues, and an immunosuppressive tumor microenvironment remain significant challenges in thermal ablation. Herein, we report a 2D/0D hybrid magnetothermal nanoplatform, FeCoNC@MnO₂QD, composed of Fe–Co dual-atom catalytic sites on nitrogen-doped carbon nanosheets decorated with MnO₂ quantum dots (QDs). Under an alternating magnetic field (AMF), the hybrid efficiently converts electromagnetic and chemical energy into localized heat and oxidative stress, enabling deep-tissue tumor ablation. The Fe–Co catalytic centers promote reactive oxygen species (ROS) generation, thereby driving ferroptosis, suppressing heat-shock responses, and inducing mitochondrial outer-membrane permeabilization and mitochondrial DNA release—collectively amplifying apoptosis and promoting irreversible tumor-cell senescence. Released Mn²⁺ and cytosolic double-stranded DNA cooperatively activate the stimulator of interferon genes (STING) pathway, triggering immunogenic cell death (ICD) and remodeling the immunosuppressive tumor microenvironment. The resulting senescence-associated secretory phenotype (SASP) suppresses tumor stemness, thereby reducing the risk of recurrence and metastasis. By integrating magnetothermal therapy, catalytic oxidative stress, ferroptosis, and immune modulation, FeCoNC@MnO₂QD effectively mitigates thermotolerance and reprograms antitumor immunity for robust solid-tumor ablation.</p>

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A 2D/0D hybrid magnetothermal platform enables multimodal energy synergy for inducing irreversible tumor senescence and promoting immune remodeling

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月28日

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  • Xiayi Liang,
  • Zhaoshen Li,
  • Guichun Zeng,
  • Juan Qin,
  • Yuan Ling,
  • Yuying Zhou,
  • Na Tao,
  • Liu Deng,
  • Duo Wang,
  • Jie Chen

摘要

Tumor thermotolerance, limited heat penetration in deep tissues, and an immunosuppressive tumor microenvironment remain significant challenges in thermal ablation. Herein, we report a 2D/0D hybrid magnetothermal nanoplatform, FeCoNC@MnO₂QD, composed of Fe–Co dual-atom catalytic sites on nitrogen-doped carbon nanosheets decorated with MnO₂ quantum dots (QDs). Under an alternating magnetic field (AMF), the hybrid efficiently converts electromagnetic and chemical energy into localized heat and oxidative stress, enabling deep-tissue tumor ablation. The Fe–Co catalytic centers promote reactive oxygen species (ROS) generation, thereby driving ferroptosis, suppressing heat-shock responses, and inducing mitochondrial outer-membrane permeabilization and mitochondrial DNA release—collectively amplifying apoptosis and promoting irreversible tumor-cell senescence. Released Mn²⁺ and cytosolic double-stranded DNA cooperatively activate the stimulator of interferon genes (STING) pathway, triggering immunogenic cell death (ICD) and remodeling the immunosuppressive tumor microenvironment. The resulting senescence-associated secretory phenotype (SASP) suppresses tumor stemness, thereby reducing the risk of recurrence and metastasis. By integrating magnetothermal therapy, catalytic oxidative stress, ferroptosis, and immune modulation, FeCoNC@MnO₂QD effectively mitigates thermotolerance and reprograms antitumor immunity for robust solid-tumor ablation.