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<p>Bone carcinoma face serious issues in its treatment owing to the complexity of the tumor microenvironment (TME) and the potential of bone metastasis. Nanotechnology provides potential strategies for addressing the intricacies and heterogeneity of tumor microenvironment in bone cancer. Recent developments in understanding the complexity of TME made it possible to precisely deliver onsite therapeutics for bone tumors, which minimized the side effects and improves the patient condition. Despite of the advancement, further exploration is needed for better therapeutic methods and preclinical research. To further enhance the detection and treatment of bone cancer, future research prospects include the progress in immunotherapies that specially targets bones and integrated therapeutic methods. This review will discuss the strategies and advancements in the diagnosis of bone carcinoma focusing on diagnostic imaging and targeted delivery of drugs for controlling and understanding of the tumor microenvironment.</p>

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Nanotechnology for understanding the tumor microenvironment heterogeneity in bone carcinoma

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月8日

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  • Zhilei Zhang,
  • Bo Li,
  • Chunxia Zhang,
  • Lu Li,
  • Libin Cui,
  • Peng Zhao,
  • Yanjun Zhang,
  • Jingang Song,
  • Dingwei Zhang,
  • Chao Wei,
  • Yan Zhang,
  • Liang Liu,
  • Bing Zhao

摘要

Bone carcinoma face serious issues in its treatment owing to the complexity of the tumor microenvironment (TME) and the potential of bone metastasis. Nanotechnology provides potential strategies for addressing the intricacies and heterogeneity of tumor microenvironment in bone cancer. Recent developments in understanding the complexity of TME made it possible to precisely deliver onsite therapeutics for bone tumors, which minimized the side effects and improves the patient condition. Despite of the advancement, further exploration is needed for better therapeutic methods and preclinical research. To further enhance the detection and treatment of bone cancer, future research prospects include the progress in immunotherapies that specially targets bones and integrated therapeutic methods. This review will discuss the strategies and advancements in the diagnosis of bone carcinoma focusing on diagnostic imaging and targeted delivery of drugs for controlling and understanding of the tumor microenvironment.