Conductive poly (vinyl alcohol)/berberine/AgNWs gellable composite film with antibacterial activity for wound dressing and acute massive hemorrhage warning

Wound infection and acute massive hemorrhage pose a huge challenge for clinical treatment. Recently, wound dressings containing natural bioactive component have been studied to prevent infection and accelerate wound healing. However, traditional wound dressings lack coping measures to the acute wound massive hemorrhage. Herein, poly (vinyl alcohol) (PVA)/berberine (BBR)/silver nanowires (AgNWs) gellable composite film was prepared by a simple thermo-crosslinking method. The film possesses the property of transforming into gel with adhesion ability after absorbing water. The incorporation of natural BBR and the loading of AgNWs make the film achieve prominent antibacterial performance. Therefore, this gellable film with adhesion ability and antibacterial performance can be used as wound dressing. Remarkably, the combination of the conductivity of AgNWs and the water absorption capability of PVA endows the gellable film with wonderful acute massive hemorrhage warning function to promoting timely treatment. The findings also elucidate excellent mechanical property and reshape ability of the film. Consequently, the gellable film provided in this study holds significant potential in wound healing and acute massive hemorrhage warning applications.