While a range of frameworks for psychedelic integration has been proposed (Dowie, 2025; Dowie & Tempone-Wiltshire, 2023), coherence remains limited due to a lack of consensus on the processes of change underlying non-ordinary states. With the medicalization of psychedelics in therapeutic contexts, frameworks that prepare, hold, and integrate psychedelic experiences have become essential. While many frameworks have been proposed, cohesion remains limited due to a lack of consensus on the processes of change underlying non-ordinary states. Building on the triphasic model for metacognitive integration in psychedelic-assisted therapy, this paper expands that model by incorporating nondual mindfulness frameworks as practical tools for preparation and integration within clinical psychedelic work. Using Analayo’s Early Buddhist Meditation, Part 2: Nondual Mindfulness (2024) as a focal point, we explore the relevance of nondual mindfulness as a clinical intervention and its value in preparing and holding psychedelic experiences. We demonstrate how technologies for conveying signlessness in the Theravāda tradition—and their analogues across global Buddhist and religious contexts—offer preparatory practices of ritual, ceremony, and philosophical inquiry that support insight into nondual experience. We suggest these traditions provide valuable models for psychedelic-assisted therapy, offering graduated pathways for re-perspectivizing non-ordinary states and attending to the nondual nature of psychedelic experiences within a structured clinical framework.
