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<p>Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR) are common age-related autoimmune disorders, often presenting with overlapping features, which complicates clinical diagnosis and management. <sup>18</sup>F-FDG PET/CT, a single imaging modality providing both anatomical and metabolic information, can concurrently reveal imaging abnormalities associated with these two inflammatory diseases, demonstrating high sensitivity and specificity in the diagnosis of GCA and PMR. This report describes a 63-year-old female patient who presented with nonspecific symptoms and was found to have pulmonary and adrenal lesions. Further investigation with <sup>18</sup>F-FDG PET/CT unexpectedly revealed abnormal vascular and joint metabolic changes, ultimately leading to the diagnosis of GCA with concomitant PMR. Additionally, a review of the literature is presented, discussing the advantages of <sup>18</sup>F-FDG PET/CT in early diagnosis and differential diagnosis, as well as the potential risk of malignancy in patients with GCA and PMR.</p>

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18F-FDG PET/CT diagnosis of giant cell arteritis complicated with polymyalgia rheumatica: a case report and literature review

  • 期刊论文

  • 发表日期：

    2026年3月12日

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  • Wenjie Zhang,
  • Yifeng Ji,
  • Xinxin Chen,
  • Xin Zhang,
  • Jun Xin

摘要

Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR) are common age-related autoimmune disorders, often presenting with overlapping features, which complicates clinical diagnosis and management. 18F-FDG PET/CT, a single imaging modality providing both anatomical and metabolic information, can concurrently reveal imaging abnormalities associated with these two inflammatory diseases, demonstrating high sensitivity and specificity in the diagnosis of GCA and PMR. This report describes a 63-year-old female patient who presented with nonspecific symptoms and was found to have pulmonary and adrenal lesions. Further investigation with 18F-FDG PET/CT unexpectedly revealed abnormal vascular and joint metabolic changes, ultimately leading to the diagnosis of GCA with concomitant PMR. Additionally, a review of the literature is presented, discussing the advantages of 18F-FDG PET/CT in early diagnosis and differential diagnosis, as well as the potential risk of malignancy in patients with GCA and PMR.