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Objective <p>To investigate the incidence and identify risk factors for transient severe motion (TSM) during the arterial phase of gadoxetate disodium (Gd-EOB-DTPA)-enhanced MRI in hepatocellular carcinoma (HCC) high-risk patients.</p> Methods <p>This multicenter study enrolled 214 high-risk HCC patients. Two radiologists independently evaluated image quality per phase with a 5-point scale. We defined TSM as the concurrent presence of severe (grade 4–5) motion artifacts on arterial phase images and minimal (grade 1–2) artifacts on all subsequent phases. To identify independent predictors, we performed logistic regression analysis and constructed a clinical nomogram for risk stratification.</p> Results <p>The incidence of TSM during arterial phase was 16.4% (35/214), with severe motion artifacts (grade 4 or 5) being the most common (17.8%, 38/214). Multivariate analysis identified four factors independently associated with TSM: old age (≥ 60&#xa0;years), high BMI (≥ 25&#xa0;kg/m<sup>2</sup>), chronic obstructive pulmonary disease (COPD), and severe pleural effusion (all <i>p</i> &lt; 0.05), with pleural effusion exhibiting the strongest effect (OR 5.33). A nomogram integrating these factors showed a TSM probability of 84.6% when all were present.</p> Conclusion <p>Old age, high BMI, COPD, and severe pleural effusion are independent risk factors for TSM of Gd-EOB-DTPA-enhanced MRI in high-risk HCC patients.</p>

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A visual nomogram for predicting the risk of transient severe motion artifacts on Gd-EOB-DTPA-enhanced MRI in high-risk hepatocellular carcinoma patients: a multicenter study

  • 期刊论文

  • 发表日期：

    2026年1月28日

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  • Fukun Shi,
  • Qian Xu,
  • Jiameng Si,
  • Yihao Yan,
  • Junjie Shu,
  • Jiaxu Liang,
  • Lifeng Wang,
  • Lan Zhang

摘要

Objective

To investigate the incidence and identify risk factors for transient severe motion (TSM) during the arterial phase of gadoxetate disodium (Gd-EOB-DTPA)-enhanced MRI in hepatocellular carcinoma (HCC) high-risk patients.

Methods

This multicenter study enrolled 214 high-risk HCC patients. Two radiologists independently evaluated image quality per phase with a 5-point scale. We defined TSM as the concurrent presence of severe (grade 4–5) motion artifacts on arterial phase images and minimal (grade 1–2) artifacts on all subsequent phases. To identify independent predictors, we performed logistic regression analysis and constructed a clinical nomogram for risk stratification.

Results

The incidence of TSM during arterial phase was 16.4% (35/214), with severe motion artifacts (grade 4 or 5) being the most common (17.8%, 38/214). Multivariate analysis identified four factors independently associated with TSM: old age (≥ 60 years), high BMI (≥ 25 kg/m2), chronic obstructive pulmonary disease (COPD), and severe pleural effusion (all p < 0.05), with pleural effusion exhibiting the strongest effect (OR 5.33). A nomogram integrating these factors showed a TSM probability of 84.6% when all were present.

Conclusion

Old age, high BMI, COPD, and severe pleural effusion are independent risk factors for TSM of Gd-EOB-DTPA-enhanced MRI in high-risk HCC patients.